Indigenous personality research often remains limited to its cultural context of origin. Previous cross-cultural examinations of indigenous models have typically focused on East–West comparisons and have paid scant attention to the predictive validity of indigenous models in new contexts. The present study addresses the replicability of the South African Personality Inventory (SAPI) and its predictive validity for family orientation and well-being in New Zealand European (n = 428) and Māori students (n = 226). The structure of the SAPI in New Zealand was equivalent to the structure identified in South Africa and had metric invariance between the two New Zealand groups. The SAPI social-relational scales explained additional variance above neuroticism, extraversion, conscientiousness, and openness in family orientation, but not in well-being. Mediation path analyses suggested that personality played a similar role for family orientation and well-being in the two groups when assessed by the SAPI, although group differences were suggested when using the Big Five Inventory. Our findings indicate that indigenously derived models, developed with the aim to represent culturally salient concepts, can be relevant well beyond their culture of origin and offer an enriched understanding of personality’s role for important outcomes across cultures.