Diabetes prevention in the Caribbean using Lifestyle Intervention and Metformin Escalation (LIME) : protocol for a hybrid type-1 effectiveness-implementation trial using a quasi-experimental study design

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dc.contributor.author Hassan, Saria
dc.contributor.author Sobers, Natasha
dc.contributor.author Paul-Charles, Joanne
dc.contributor.author Herbert, Joseph
dc.contributor.author Dharamraj, Kavita
dc.contributor.author Cruz, Elsie
dc.contributor.author Garcia, Enid
dc.contributor.author Fredericks, Lyna
dc.contributor.author Desai, Mayur M.
dc.contributor.author Roy, Shireen
dc.contributor.author Williams, Sharon
dc.contributor.author Linnander, Erika
dc.contributor.author Crusto, Cindy A.
dc.contributor.author Horowitz, Carol R.
dc.contributor.author Arniella, Guedy
dc.contributor.author Cattamanchi, Adithya
dc.contributor.author Adams, Oswald P.
dc.contributor.author Nunez-Smith, Marcella
dc.date.accessioned 2022-07-28T04:53:48Z
dc.date.available 2022-07-28T04:53:48Z
dc.date.issued 2021-06
dc.description.abstract BACKGROUND : Globally, several diabetes prevention interventions have been shown to be cost-effective, yet they have had limited adaptation, implementation, and evaluation in the Caribbean and among Caribbean-descent individuals, where the burden of type 2 diabetes is high. We report on the protocol for the Lifestyle Intervention with Metformin Escalation (LIME) study – an evidence-based diabetes prevention intervention to reduce the incidence of diabetes among Caribbean-descent individuals with prediabetes. METHODS : LIME is a hybrid type-I effectiveness-implementation quasi-experimental study taking place in 4 clinical sites in Barbados, Trinidad, the U.S. Virgin Islands, and Puerto Rico. LIME targets individuals who self-identify as Caribbean or Caribbean-descent and have high-risk prediabetes with a hemoglobin A1c (HbA1c) between 6 and 6.4%. Eligible participants in the intervention arm are enrolled in a six-week lifestyle modification workshop. Six months later, individuals who have not lost at least 5% of their bodyweight or continue to have an HbA1c of 6% or higher are prescribed metformin medication. In total, participants are followed for one year. The primary effectiveness outcome is proportion of individuals who lower their HbA1c below 6%. DISCUSSION : LIME is a unique diabetes prevention intervention for Caribbean and Caribbean-descent individuals. LIME utilizes a tailored lifestyle change curriculum, incorporates appropriate metformin prescribing when lifestyle change alone is insufficient, targets the highest-risk individuals with prediabetes, and is based in a clinical setting to ensure sustainability. en_US
dc.description.department Psychology en_US
dc.description.librarian am2022 en_US
dc.description.sponsorship The National Institutes of Health/National Institute on Minority Health and Health Disparities (NIH/NIMHD) and the National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/ NHLBI). en_US
dc.description.uri https://http//www.elsevier.com/locate/conctc en_US
dc.identifier.citation Hassan, S., Sobers, N., Paul-Charles, J. et al. 2021, 'Diabetes prevention in the Caribbean using Lifestyle Intervention and Metformin Escalation (LIME) : protocol for a hybrid type-1 effectiveness-implementation trial using a quasi-experimental study design', Contemporary Clinical Trials Communications, vol. 22, art. 100750, pp. 1-7, doi : :10.1016/j.conctc.2021.100750. en_US
dc.identifier.issn 2451-8654
dc.identifier.other 10.1016/j.conctc.2021.100750
dc.identifier.uri https://repository.up.ac.za/handle/2263/86507
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2021 The Authors. This is an open access article under the CC BY-NC-ND license. en_US
dc.subject Diabetes prevention en_US
dc.subject Implementation science en_US
dc.subject Hybrid-I en_US
dc.subject Metformin en_US
dc.subject Caribbean en_US
dc.subject Adaptation en_US
dc.subject Lifestyle intervention with metformin escalation (LIME) en_US
dc.title Diabetes prevention in the Caribbean using Lifestyle Intervention and Metformin Escalation (LIME) : protocol for a hybrid type-1 effectiveness-implementation trial using a quasi-experimental study design en_US
dc.type Article en_US


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