Abstract:
Keratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which
are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises
two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review
provides a holistic literature assessment of the origin, diagnosis methods, contributing factors, and
current topical treatments of KC. Additionally, it explores the increase in KC cases that occurred
globally over the past ten years. One of the principal concepts highlighted in this article is the
adverse effects linked to conventional treatment methods of KC and how novel treatment strategies
that combine phytochemistry and transdermal drug delivery systems offer an alternative approach
for treatment. However, more in vitro and in vivo studies are required to fully assess the efficacy,
mechanism of action, and safety profile of these phytochemical based transdermal chemotherapeutics.
