Pathogenesis of keratinocyte carcinomas and the therapeutic potential of medicinal plants and phytochemicals
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Date
Authors
Josiah, Andrea Jess
Twilley, Danielle
Pillai, Sreejarani Kesavan
Ray, Suprakas Sinha
Lall, Namrita
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Keratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which
are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises
two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review
provides a holistic literature assessment of the origin, diagnosis methods, contributing factors, and
current topical treatments of KC. Additionally, it explores the increase in KC cases that occurred
globally over the past ten years. One of the principal concepts highlighted in this article is the
adverse effects linked to conventional treatment methods of KC and how novel treatment strategies
that combine phytochemistry and transdermal drug delivery systems offer an alternative approach
for treatment. However, more in vitro and in vivo studies are required to fully assess the efficacy,
mechanism of action, and safety profile of these phytochemical based transdermal chemotherapeutics.
Description
Keywords
Medicinal plants, Phytochemistry, Transdermal drug delivery systems, Keratinocyte carcinoma (KC), Basal cell carcinoma (BCC), Squamous cell carcinoma (SCC)
Sustainable Development Goals
Citation
Josiah, A.J.; Twilley, D.;
Pillai, S.K.; Ray, S.S.; Lall, N.
Pathogenesis of Keratinocyte
Carcinomas and the Therapeutic
Potential of Medicinal Plants and
Phytochemicals. Molecules 2021, 26,
1979. https://DOI.org/10.3390/molecules26071979.