dc.contributor.author |
Buyens, Dominique M.S.
|
|
dc.contributor.author |
Pilcher, Lynne A.
|
|
dc.contributor.author |
Roduner, Emil
|
|
dc.date.accessioned |
2022-03-29T10:50:40Z |
|
dc.date.available |
2022-03-29T10:50:40Z |
|
dc.date.issued |
2021-10 |
|
dc.description.abstract |
Rare anionic forms of nucleic acids play a significant biological role and lead to spontaneous mutations and replication and translational errors. There is a lack of information surrounding the stability and reactivity of these forms. Ion pairs of mono-sodium and -potassium salts of adenine exist in DMSO solution with possible cation coordination sites at the N1, N7 and N9 atoms of the purine ring. At increasing concentrations π-π stacked dimers are the predominant species of aggregates followed by higher order aggregation governed by coordination to metal cations in which the type of counter ion present has a central role in the aggregate formation. |
en_ZA |
dc.description.department |
Chemistry |
en_ZA |
dc.description.librarian |
hj2022 |
en_ZA |
dc.description.sponsorship |
National Research Foundation. Open access funding enabled and organized by Projekt DEAL. |
en_ZA |
dc.description.uri |
https://onlinelibrary.wiley.com/journal/14397641 |
en_ZA |
dc.identifier.citation |
Buyens, D.M.S., Pilcher, L.A. & Roduner, E. 2021, 'Towards a molecular understanding of cation-anion interactions and self-aggregation of adeninate salts in DMSO by NMR and UV spectroscopy and crystallography', ChemPhysChem, vol. 22, no. 19, pp. 2025-2033, doi : 10.1002/cphc.202100098. |
en_ZA |
dc.identifier.issn |
1439-4235 (print) |
|
dc.identifier.issn |
1439-7641 (online) |
|
dc.identifier.other |
10.1002/cphc.202100098 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/84688 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Wiley |
en_ZA |
dc.rights |
© 2021 The Authors. ChemPhysChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License. |
en_ZA |
dc.subject |
Nucleobases |
en_ZA |
dc.subject |
Aggregation |
en_ZA |
dc.subject |
Hydrogen bonding |
en_ZA |
dc.subject |
Stacking interactions |
en_ZA |
dc.subject |
Ion-pairing |
en_ZA |
dc.title |
Towards a molecular understanding of cation-anion interactions and self-aggregation of adeninate salts in DMSO by NMR and UV spectroscopy and crystallography |
en_ZA |
dc.type |
Article |
en_ZA |