An illustrated forensic pathology case : bilateral putaminal hemorrhages after methanol ingestion

Show simple item record Blumenthal, Ryan Roth, Lisa Barbara 2022-02-08T09:02:46Z 2021-09
dc.description.abstract We report the case of a 45-year old African male, who presented to the Emergency Department with severe metabolic lactic acidosis and confusion secondary to ingestion of methylated spirits. Methylated spirits is a common household product. He was declared brain dead the following day. A medico-legal autopsy was performed immediately thereafter in accordance with the national regulations. Autopsy examination demonstrated bilateral putaminal haemorrhages. Bilateral putaminal haemorrhages, in combination with metabolic lactic acidosis and visual impairment, is pathognomonic for methanol ingestion. Why specifically the putamen is affected by methanol poisoning while other structures of the basal ganglia stay intact, is addressed in this paper. The selectivity of putaminal damage is thought to be due to a higher sensitivity to the acidic metabolite formic acid; another theory suggests phylogenetical differences to the other basal ganglia. en_ZA
dc.description.department Forensic Medicine en_ZA
dc.description.embargo 2022-09-01
dc.description.librarian hj2022 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Blumenthal, R. & Barbara Roth, L. (2021). An Illustrated Forensic Pathology Case. The American Journal of Forensic Medicine and Pathology, 42 (3), e61-e63. doi: 10.1097/PAF.0000000000000666. en_ZA
dc.identifier.issn 0195-7910 (print)
dc.identifier.issn 1533-404X (online)
dc.identifier.other 10.1097/PAF.0000000000000666
dc.language.iso en en_ZA
dc.publisher Lippincott, Williams & Wilkins en_ZA
dc.rights © 2021 Wolters Kluwer Health, Inc. All rights reserved. This is a non-final version of an article published in final form in American Journal of Forensic Medicine and Pathology, vol. 42, no. 3, pp. e61–e63, 2021. doi : 10.1097/PAF.0000000000000666. en_ZA
dc.subject Metabolic lactic acidosis en_ZA
dc.subject Confusion en_ZA
dc.subject Methanol ingestion en_ZA
dc.subject Chronic ethanol use en_ZA
dc.title An illustrated forensic pathology case : bilateral putaminal hemorrhages after methanol ingestion en_ZA
dc.type Postprint Article en_ZA

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