An illustrated forensic pathology case : bilateral putaminal hemorrhages after methanol ingestion

dc.contributor.authorBlumenthal, Ryan
dc.contributor.authorRoth, Lisa Barbara
dc.contributor.emailryan.blumenthal@up.ac.zaen_ZA
dc.date.accessioned2022-02-08T09:02:46Z
dc.date.issued2021-09
dc.description.abstractWe report the case of a 45-year old African male, who presented to the Emergency Department with severe metabolic lactic acidosis and confusion secondary to ingestion of methylated spirits. Methylated spirits is a common household product. He was declared brain dead the following day. A medico-legal autopsy was performed immediately thereafter in accordance with the national regulations. Autopsy examination demonstrated bilateral putaminal haemorrhages. Bilateral putaminal haemorrhages, in combination with metabolic lactic acidosis and visual impairment, is pathognomonic for methanol ingestion. Why specifically the putamen is affected by methanol poisoning while other structures of the basal ganglia stay intact, is addressed in this paper. The selectivity of putaminal damage is thought to be due to a higher sensitivity to the acidic metabolite formic acid; another theory suggests phylogenetical differences to the other basal ganglia.en_ZA
dc.description.departmentForensic Medicineen_ZA
dc.description.embargo2022-09-01
dc.description.librarianhj2022en_ZA
dc.description.urihttps://journals.lww.com/amjforensicmedicine/pages/default.aspxen_ZA
dc.identifier.citationBlumenthal, R. & Barbara Roth, L. (2021). An Illustrated Forensic Pathology Case. The American Journal of Forensic Medicine and Pathology, 42 (3), e61-e63. doi: 10.1097/PAF.0000000000000666.en_ZA
dc.identifier.issn0195-7910 (print)
dc.identifier.issn1533-404X (online)
dc.identifier.other10.1097/PAF.0000000000000666
dc.identifier.urihttp://hdl.handle.net/2263/83673
dc.language.isoenen_ZA
dc.publisherLippincott, Williams & Wilkinsen_ZA
dc.rights© 2021 Wolters Kluwer Health, Inc. All rights reserved. This is a non-final version of an article published in final form in American Journal of Forensic Medicine and Pathology, vol. 42, no. 3, pp. e61–e63, 2021. doi : 10.1097/PAF.0000000000000666.en_ZA
dc.subjectMetabolic lactic acidosisen_ZA
dc.subjectConfusionen_ZA
dc.subjectMethanol ingestionen_ZA
dc.subjectChronic ethanol useen_ZA
dc.subject.otherHealth sciences articles SDG-03
dc.subject.otherSDG-03: Good health and well-being
dc.titleAn illustrated forensic pathology case : bilateral putaminal hemorrhages after methanol ingestionen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Blumenthal_Illustrated_2021.pdf
Size:
545.96 KB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: