dc.contributor.author |
Liang, Yue
|
|
dc.contributor.author |
Zhang, Qi
|
|
dc.contributor.author |
Yang, Xueyuan
|
|
dc.contributor.author |
Li, Ying
|
|
dc.contributor.author |
Zhang, Xuke
|
|
dc.contributor.author |
Li, Yuhao
|
|
dc.contributor.author |
Du, Qing
|
|
dc.contributor.author |
Jin, Da-Qing
|
|
dc.contributor.author |
Cui, Jianlin
|
|
dc.contributor.author |
Lall, Namrita
|
|
dc.contributor.author |
Tuerhong, Muhetaer
|
|
dc.contributor.author |
Lee, Dongho
|
|
dc.contributor.author |
Abudukeremu, Munira
|
|
dc.contributor.author |
Xu, Jing
|
|
dc.contributor.author |
Shuai, Ling
|
|
dc.contributor.author |
Guo, Yuanqiang
|
|
dc.date.accessioned |
2021-11-25T10:21:58Z |
|
dc.date.available |
2021-11-25T10:21:58Z |
|
dc.date.issued |
2020-05 |
|
dc.description.abstract |
A phytochemical investigation to obtain bioactive substances as lead compounds or agents for cancer led to the obtainment of six new and two known clerodane diterpenoids from the leaves of Casearia kurzii. Their structures were elucidated using NMR techniques and electronic circular dichroism (ECD) calculations. The subsequent biological cytotoxicity evaluation of these isolates toward human lung cancer A549, human cervical cancer HeLa, human chronic myeloid leukemia K562, and human hepatocellular carcinoma HepG2 was carried out. The most active compound 4 with an IC50 value of 9.7 μM against HepG2 cells was selected to examine the cytotoxic mechanism, which induced the apoptosis and arrested the HepG2 cell cycle at S stage. The in vivo zebrafish experiments revealed that compound 4 had the property of inhibiting tumor proliferation and migration. |
en_ZA |
dc.description.department |
Plant Production and Soil Science |
en_ZA |
dc.description.librarian |
hj2021 |
en_ZA |
dc.description.sponsorship |
The National Key Research and Development Program of China, the National Natural Science Foundation of China, Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region. |
en_ZA |
dc.description.uri |
http://www.elsevier.com/ locate/bmcl |
en_ZA |
dc.identifier.citation |
Liang, Y., Zhang, Q., Yang, X. et al. 2020, 'Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities', Bioorganic Chemistry, vol. 98, art. 103741, pp. 1-10. |
en_ZA |
dc.identifier.issn |
0045-2068 |
|
dc.identifier.other |
10.1016/j.bioorg.2020.103741 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/82848 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Elsevier |
en_ZA |
dc.rights |
© 2020 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Bioorganic Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Bioorganic Chemistry, vol. 98, art. 103741, pp. 1-10, 2020. doi : 10.1016/j.bioorg.2020.103741. |
en_ZA |
dc.subject |
Zebrafish xenograft model |
en_ZA |
dc.subject |
Cytotoxic activities |
en_ZA |
dc.subject |
Apoptosis |
en_ZA |
dc.subject |
Cell cycle |
en_ZA |
dc.subject |
Clerodane diterpenoids |
en_ZA |
dc.subject |
Casearia kurzii |
en_ZA |
dc.subject |
Electronic circular dichroism (ECD) |
en_ZA |
dc.title |
Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities |
en_ZA |
dc.type |
Postprint Article |
en_ZA |