Osteogenesis imperfecta (OI) is a metabolic bone disorder commonly encountered in orthopaedic practice within the context of a
multidisciplinary team. Although relatively rare, it is among the most researched of the skeletal dysplasias, making it challenging for
the general orthopaedic surgeon to keep abreast with current evidence. The aim of this review article is to provide a comprehensive
overview of OI for the general orthopaedic surgeon. It touches on the relevant epidemiology, pathology and clinical aspects of the
condition. A discussion of the background and current topical issues surrounding the classification systems, and the medical and
orthopaedic management aspects follows. The main focus of this review is on the peri-operative orthopaedic care of the appendicular
musculoskeletal system. We trust it will equip the general orthopaedic surgeon with concise, up-to-date and relevant information to
efficiently manage affected patients and caregivers in South Africa.