Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra

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Authors

Xing, Honghong
An, Lijun
Song, Ziteng
Li, Shanshan
Wang, Huimei
Wang, Chunyan
Zhang, Jie
Tuerhong, Muhetaer
Abudukeremu, Munira
Li, Dihua

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Volume Title

Publisher

American Chemical Society

Abstract

Ten new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.

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Keywords

Ent-kaurane diterpenoids, Isodon serra, Spectroscopic methods, Electronic circular dichroism (ECD), Anti-inflammatory assay, Inducible nitric oxide synthase (iNOS)

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Citation

Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra. Journal of Natural Products 2020, 83, 10, 2844–2853, https://doi.org/10.1021/acs.jnatprod.9b01281.