Anti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra

dc.contributor.authorXing, Honghong
dc.contributor.authorAn, Lijun
dc.contributor.authorSong, Ziteng
dc.contributor.authorLi, Shanshan
dc.contributor.authorWang, Huimei
dc.contributor.authorWang, Chunyan
dc.contributor.authorZhang, Jie
dc.contributor.authorTuerhong, Muhetaer
dc.contributor.authorAbudukeremu, Munira
dc.contributor.authorLi, Dihua
dc.contributor.authorLee, Dongho
dc.contributor.authorXu, Jing
dc.contributor.authorLall, Namrita
dc.contributor.authorGuo, Yuanqiang
dc.date.accessioned2021-09-13T13:11:58Z
dc.date.issued2020-09
dc.description.abstractTen new ent-kaurane diterpenoids, including two pairs of epimers 1/2 and 4/5 and a 6,7-seco-ent-kauranoid 10, were obtained from the aerial parts of Isodon serra. The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. An anti-inflammatory assay was applied to evaluate their nitric oxide (NO) inhibitory activities by using LPS-stimulated BV-2 cells. Compounds 1 and 9 exhibited notable NO production inhibition with IC50 values of 15.6 and 7.3 μM, respectively. Moreover, the interactions of some bioactive diterpenoids with inducible nitric oxide synthase (iNOS) were explored by employing molecular docking studies.en_ZA
dc.description.departmentPlant Production and Soil Scienceen_ZA
dc.description.embargo2021-09-29
dc.description.librarianhj2021en_ZA
dc.description.urihttps://pubs.acs.org/journal/jnprdfen_ZA
dc.identifier.citationAnti-Inflammatory ent-Kaurane Diterpenoids from Isodon serra. Journal of Natural Products 2020, 83, 10, 2844–2853, https://doi.org/10.1021/acs.jnatprod.9b01281.en_ZA
dc.identifier.issn0163-3864 (print)
dc.identifier.issn1520-6025 (online)
dc.identifier.other10.1021/acs.jnatprod.9b01281
dc.identifier.urihttp://hdl.handle.net/2263/81799
dc.language.isoenen_ZA
dc.publisherAmerican Chemical Societyen_ZA
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, © 2020 American Chemical Society and American Society of Pharmacognosy, after peer review and technical editing by the publisher. To access https://pubs.acs.org/journal/jnprdf.en_ZA
dc.subjectEnt-kaurane diterpenoidsen_ZA
dc.subjectIsodon serraen_ZA
dc.subjectSpectroscopic methodsen_ZA
dc.subjectElectronic circular dichroism (ECD)en_ZA
dc.subjectAnti-inflammatory assayen_ZA
dc.subjectInducible nitric oxide synthase (iNOS)en_ZA
dc.titleAnti-Inflammatory ent-Kaurane Diterpenoids from Isodon serraen_ZA
dc.typePostprint Articleen_ZA

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