The immunology of mind control : exploring the relationship between the microbiome and the brain (Part V)

Show simple item record Karsas, Maria Green, Robin J. Lamb, Greg 2021-07-28T07:32:56Z 2021-07-28T07:32:56Z 2020-10
dc.description.abstract The final part of this series concludes the evaluation of the relationship between the human species and the human gut microbiome, focusing on whether their relationship is symbiotic, parasitic or somewhere in between. The possibilities based on animal studies are explored and compared to scientific facts proven in human beings. In particular, close attention is paid to the relationship between the gut microbiome and central nervous system, and the effect of this on human behaviour. This relationship is termed the 'microbiome-gut-brain axis'. The gut microbiome has an influence on stress (both acute and chronic), anxiety, loneliness and depression, as well as odour and attraction, through a number of pathways. It has also been associated with the development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and with associated cognitive decline. It has also been postulated to play a role in schizophrenia. Since the common treatments used for these conditions are not equally effective in all patients, it is vital for clinicians to explore other avenues to be used as therapeutic targets. The gut microbiome, in particular, requires further research in order to aid the development of future therapies for certain conditions. The role of vitamin D in relation to the gut microbiome and the brain, and the impact of the gut microbiome on autoimmunity and systemic disease and how this affects the brain is explored. Randomised controlled trials in human beings are greatly needed to prove or disprove the effects of the gut microbiome on complex psychiatric diseases. en_ZA
dc.description.department Paediatrics and Child Health en_ZA
dc.description.librarian hj2021 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Karsas, M., Green, R.J., and Lamb, G. 2020. 'The Immunology of Mind Control: Exploring the Relationship between the Microbiome and the Brain (part V)', Current Allergy and Clinical Immunology, vol. 33, no. 3, pp. 142–148. en_ZA
dc.identifier.issn 1473-6322 (online)
dc.identifier.issn 1528-4050 (print)
dc.identifier.other 10.10520/ejc-caci-v33-n3-a4
dc.language.iso en en_ZA
dc.publisher Allergy Society of South Africa en_ZA
dc.rights © 2020, Allergy Society of South Africa (ALLSA) en_ZA
dc.subject Immunology en_ZA
dc.subject Mind control en_ZA
dc.subject Relationship en_ZA
dc.subject Microbiome en_ZA
dc.subject Brain en_ZA
dc.title The immunology of mind control : exploring the relationship between the microbiome and the brain (Part V) en_ZA
dc.type Article en_ZA

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