[68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients : a comparison with18f[fdg] pet imaging

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dc.contributor.author Lawal, Ismaheel
dc.contributor.author Popoola, Gbenga O.
dc.contributor.author Mahapane, Johncy
dc.contributor.author Kaufmann, Jens
dc.contributor.author Davis, Cindy
dc.contributor.author Ndlovu, Honest
dc.contributor.author Maserumule, L.C. (Letjie)
dc.contributor.author Mokoala, K.M.G. (Kgomotso)
dc.contributor.author Bouterfa, Hakim
dc.contributor.author Wester, Hans-Jurgen
dc.contributor.author Zeevaart, Jan Rijn
dc.contributor.author Sathekge, Mike Machaba
dc.date.accessioned 2021-02-20T06:13:37Z
dc.date.available 2021-02-20T06:13:37Z
dc.date.issued 2020-12
dc.description.abstract People living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target–background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.librarian pm2021 en_ZA
dc.description.uri http://www.mdpi.com/journal/biomolecules en_ZA
dc.identifier.citation Lawal, I.O., Popoola, G.O., Mahapane, J. et al. 2020, '[68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients: a comparison with18f[fdg] pet imaging', Biomolecules, vol. 10, no. 12, art. 1629, pp. 1-12. en_ZA
dc.identifier.issn 2218-273X (online)
dc.identifier.other 10.3390/biom10121629
dc.identifier.uri http://hdl.handle.net/2263/78785
dc.language.iso en en_ZA
dc.publisher MDPI en_ZA
dc.rights © 2020 by the authors. Licensee: MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). en_ZA
dc.subject HIV infection en_ZA
dc.subject Arterial inflammation en_ZA
dc.subject Atherosclerotic cardiovascular diseases en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject People living with human immunodeficiency virus (PLHIV) en_ZA
dc.subject Atherosclerotic cardiovascular disease (ASCVD) en_ZA
dc.subject Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) en_ZA
dc.subject Gallium-68 pentixafor positron emission tomography/computed tomography ([68Ga]Ga-pentixafor PET/CT) en_ZA
dc.title [68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients : a comparison with18f[fdg] pet imaging en_ZA
dc.type Article en_ZA


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