[68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients : a comparison with18f[fdg] pet imaging

dc.contributor.authorLawal, Ismaheel Opeyemi
dc.contributor.authorPopoola, Gbenga O.
dc.contributor.authorMahapane, Johncy
dc.contributor.authorKaufmann, Jens
dc.contributor.authorDavis, Cindy
dc.contributor.authorNdlovu, Honest
dc.contributor.authorMaserumule, Letjie C.
dc.contributor.authorMokoala, Kgomotso M.G.
dc.contributor.authorBouterfa, Hakim
dc.contributor.authorWester, Hans-Jurgen
dc.contributor.authorZeevaart, Jan Rijn
dc.contributor.authorSathekge, Mike Machaba
dc.contributor.emailmike.sathekge@up.ac.zaen_ZA
dc.date.accessioned2021-02-20T06:13:37Z
dc.date.available2021-02-20T06:13:37Z
dc.date.issued2020-12
dc.description.abstractPeople living with human immunodeficiency virus (PLHIV) have excess risk of atherosclerotic cardiovascular disease (ASCVD). Arterial inflammation is the hallmark of atherogenesis and its complications. In this study we aimed to perform a head-to-head comparison of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) and Gallium-68 pentixafor positron emission tomography/computed tomography [68Ga]Ga-pentixafor PET/CT for quantification of arterial inflammation in PLHIV. We prospectively recruited human immunodeficiency virus (HIV)-infected patients to undergo [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT within two weeks of each other. We quantified the levels of arterial tracer uptake on both scans using maximum standardized uptake value (SUVmax) and target–background ratio. We used Bland and Altman plots to measure the level of agreement between tracer quantification parameters obtained on both scans. A total of 12 patients were included with a mean age of 44.67 ± 7.62 years. The mean duration of HIV infection and mean CD+ T-cell count of the study population were 71.08 ± 37 months and 522.17 ± 260.33 cells/µL, respectively. We found a high level of agreement in the quantification variables obtained using [18F]FDG PET and [68Ga]Ga-pentixafor PET. There is a good level of agreement in the arterial tracer quantification variables obtained using [18F]FDG PET/CT and [68Ga]Ga-pentixafor PET/CT in PLHIV. This suggests that [68Ga]Ga-pentixafor may be applied in the place of [18F]FDG PET/CT for the quantification of arterial inflammation.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.librarianpm2021en_ZA
dc.description.urihttp://www.mdpi.com/journal/biomoleculesen_ZA
dc.identifier.citationLawal, I.O., Popoola, G.O., Mahapane, J. et al. 2020, '[68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients: a comparison with18f[fdg] pet imaging', Biomolecules, vol. 10, no. 12, art. 1629, pp. 1-12.en_ZA
dc.identifier.issn2218-273X (online)
dc.identifier.other10.3390/biom10121629
dc.identifier.urihttp://hdl.handle.net/2263/78785
dc.language.isoenen_ZA
dc.publisherMDPIen_ZA
dc.rights© 2020 by the authors. Licensee: MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_ZA
dc.subjectHIV infectionen_ZA
dc.subjectArterial inflammationen_ZA
dc.subjectAtherosclerotic cardiovascular diseasesen_ZA
dc.subjectHuman immunodeficiency virus (HIV)en_ZA
dc.subjectPeople living with HIV (PLHIV)en_ZA
dc.subjectAtherosclerotic cardiovascular disease (ASCVD)en_ZA
dc.subjectFluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT)en_ZA
dc.subjectGallium-68 pentixafor positron emission tomography/computed tomography ([68Ga]Ga-pentixafor PET/CT)en_ZA
dc.title[68ga]ga-pentixafor for pet imaging of vascular expression of cxcr-4 as a marker of arterial inflammation in hiv-infected patients : a comparison with18f[fdg] pet imagingen_ZA
dc.typeArticleen_ZA

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