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Browsing Veterinary Science by UP Author "Thema, Nontobeko"
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Thema, Nontobeko; Pretorius, Alri; Tshilwane, Selaelo Ivy; Liebenberg, Junita; Steyn, Helena; Van Kleef, Mirinda (AOSIS OpenJournals, 2016-08-30)Secreted proteins are reported to induce cell-mediated immunity characterised by the production of interferon-gamma (IFN)-γ. In this study three open reading frames (ORFs) (Erum8060, Erum7760, Erum5000) encoding secreted ...
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Thema, Nontobeko; Tshilwane, Selaelo Ivy; Son, L.; Smith, R.M.; Faber, Frederika E.; Steyn, Helena C.; Van Kleef, Mirinda; Liebenberg, Junita; Pretorius, Alri (Elsevier, 2019-01)Since CD8+ T cells play an important role in resistance to infection with heartwater, effective vaccines against this disease will likely require identification of antigens that contain CD8+ T cell epitopes responsible for ...
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Thema, Nontobeko; Tshilwane, Selaelo Ivy; Pretorius, Alri; Son, L.; Smith, R.M.; Steyn, Helena C.; Liebenberg, Junita; Van Kleef, Mirinda (Elsevier, 2019-03)Several studies have shown that cytotoxic T lymphocytes (CTL) require CD4 + Th1 epitopes to generate strong immune responses to intracellular pathogens. However, not much is known about Ehrlichia ruminantium epitopes, ...
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Tshilwane, Selaelo Ivy; Thema, Nontobeko; Steyn, Helena C.; Van Kleef, Mirinda; Pretorius, Alri (Elsevier, 2019-07)Previously, a heartwater experimental DNA vaccine provided 100% protection following laboratory challenge with Ehrlichia ruminantium administered by needle but not against an E. ruminantium tick challenge in the field. A ...
Now showing items 1-4 of 4