Browsing Veterinary Science by Subject "E. ruminantium"

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Ehrlichia ruminantium antigens and peptides induce cytotoxic T cell responses in vitro

Thema, Nontobeko; Tshilwane, Selaelo Ivy; Son, L.; Smith, R.M.; Faber, Frederika E.; Steyn, Helena C.; Van Kleef, Mirinda; Liebenberg, Junita; Pretorius, Alri (Elsevier, 2019-01)

Since CD8+ T cells play an important role in resistance to infection with heartwater, effective vaccines against this disease will likely require identification of antigens that contain CD8+ T cell epitopes responsible for ...
In vitro and in vivo evaluation of five low molecular weight proteins of Ehrlichia ruminantium as potential vaccine components

Sebatjane, Selaelo Ivy; Pretorius, Alri; Liebenberg, Junita; Steyn, H.; Van Kleef, Mirinda (Elsevier, 2010-10)

Low molecular weight (LMW) proteins of E. ruminantium can induce proliferation of immune peripheral blood mononuclear cells (PBMCs) and the production of interferongamma (IFN-y ) by CD4+-enriched T-cells. In this study, ...
Preparation and in vitro characterisation of Ehrlichia ruminantium plasmid DNA and protein sencapsulated into and DNA adsorbed onto biodegradable microparticles

Tshikhudoa, Ndavheleseni; Pretorius, Alri; Putterill, John Fraser; Van Kleef, Mirinda (Elsevier, 2010-08)

Four E. ruminantium 1H12 open reading frames and their proteins known to protect sheep against heartwater needle challenge were encapsulated into, or adsorbed onto poly (d,l-lactide-co-glycolide) microparticles. Microspheres ...

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