dc.contributor.author |
Ajani, Olayinka O.
|
|
dc.contributor.author |
Akande, Maria M.
|
|
dc.contributor.author |
October, Natasha
|
|
dc.contributor.author |
Siyanbola, Tolutope O.
|
|
dc.contributor.author |
Aderohunmu, Damilola Victoria
|
|
dc.contributor.author |
Akinsiku, Anuoluwa A.
|
|
dc.contributor.author |
Olorunshola, Shade J.
|
|
dc.date.accessioned |
2020-07-15T06:55:48Z |
|
dc.date.available |
2020-07-15T06:55:48Z |
|
dc.date.issued |
2019-07-01 |
|
dc.description.abstract |
A variety of 3-(5-(substituted-phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives
3a–j were synthesized through microwave assisted thermal annulation of corresponding
a,b-unsaturated ketones (chalcones) 2a–j via hydrazinolysis. Chalcones 2a–j were
prepared from 3-acetyl-coumarin 1 which was previously accessed by Pechmann condensation
reaction of salicylaldehyde. The series of pyrazoline-based coumarin motifs 3a–j synthesized,
were structurally confirmed by analytical and spectral data. They were then evaluated
for their antimicrobial activities using agar diffusion method. The result showed that microwave
assisted method (MAM) for the reaction was remarkably successful and gave the targeted
products 3a–j in higher yields at shorter reaction times compared to conventional
synthetic method (CSM). The results showed that these skeletal frameworks exhibited
marked potency as antibacterial agents. The most active antibacterial agent was 3-(5-(4-
(diethylamino) phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one 3j with MIC and MBC
values of 3.92 ± 0.22 mg/mL and 7.82 ± 0.43 mg/mL respectively. |
en_ZA |
dc.description.department |
Chemistry |
en_ZA |
dc.description.librarian |
am2020 |
en_ZA |
dc.description.sponsorship |
The World Academy of Sciences (TWAS) |
en_ZA |
dc.description.uri |
https://www.tandfonline.com/loi/tabs20 |
en_ZA |
dc.identifier.citation |
Olayinka O. Ajani, Maria M. Akande, Natasha October, Tolutope O. Siyanbola,
Damilola V. Aderohunmu, Anuoluwa A. Akinsiku & Shade J. Olorunshola (2019) Microwave
assisted synthesis, characterization and investigation of antibacterial activity of 3-(5-(substitutedphenyl)-
4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one derivatives, Arab Journal of Basic and
Applied Sciences, 26:1, 362-375, DOI: 10.1080/25765299.2019.1632141. |
en_ZA |
dc.identifier.issn |
2576-5299 (online) |
|
dc.identifier.other |
10.1080/25765299.2019.1632141 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/75231 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Taylor and Francis Open |
en_ZA |
dc.rights |
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the University of Bahrain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. |
en_ZA |
dc.subject |
Microwave synthesis |
en_ZA |
dc.subject |
Pyrazoline |
en_ZA |
dc.subject |
Coumarin motifs |
en_ZA |
dc.subject |
Antibacterial |
en_ZA |
dc.subject |
Gentamicin |
en_ZA |
dc.subject |
Microwave assisted method (MAM) |
en_ZA |
dc.subject |
Conventional synthetic method (CSM) |
en_ZA |
dc.title |
Microwave assisted synthesis, characterization and investigation of antibacterial activity of 3-(5- (substituted-phenyl)-4,5-dihydro-1H-pyrazol-3- yl)-2H-chromen-2-one derivatives |
en_ZA |
dc.type |
Article |
en_ZA |