Please be advised that the site will be down for maintenance on Sunday, September 1, 2024, from 08:00 to 18:00, and again on Monday, September 2, 2024, from 08:00 to 09:00. We apologize for any inconvenience this may cause.
dc.contributor.author | Van Heerden, Jaques![]() |
|
dc.contributor.author | Geel, Jennifer![]() |
|
dc.contributor.author | Hendricks, Marc![]() |
|
dc.contributor.author | Wouters, Kristien![]() |
|
dc.contributor.author | Buchner, Ane![]() |
|
dc.contributor.author | Naidu, Gita![]() |
|
dc.contributor.author | Hadley, G.P.![]() |
|
dc.contributor.author | Du Plessis, Jan![]() |
|
dc.contributor.author | Van Emmenes, Barry![]() |
|
dc.contributor.author | Van Zyl, Anel![]() |
|
dc.contributor.author | Vermeulen, Johani![]() |
|
dc.contributor.author | Kruger, Mariana![]() |
|
dc.date.accessioned | 2020-05-26T15:04:08Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Achieving remission after induction therapy in high-risk neuroblastoma (HR-NB) is of significant prognostic importance. This study investigated remission after induction-chemotherapy using three standard neuroblastoma protocols in the South African (SA) setting. Retrospective data of 261 patients with HR-NB diagnosed between January 2000 and December 2016, who completed induction chemotherapy with standard treatment protocols were evaluated. The treatment protocols were either OPEC/OJEC or the St Jude NB84 protocol (NB84) or rapid COJEC (rCOJEC). The postinduction metastatic complete remission (mCR) rate, 2-year overall survival (OS) and 2-year event free survival (EFS) were determined as comparative denominators. The majority (48.3%; n = 126) received OPEC/OJEC, while 70 patients received (26.8%) rCOJEC and 65 (24.9%) NB84. Treatment with NB84 had the best mCR rate (36.9%), followed by OPEC/OJEC (32.5%) and rCOJEC (21.4%). The 2-year OS of treatment with NB84 was 41% compared to OPEC/OJEC (35%) and rCOJEC (24%) (p = 0.010). The 2-year EFS of treatment with NB84 was 37% compared to OPEC/OJEC (35%) and rCOJEC (18%) (p = 0.008). OPEC/OJEC had the least treatment-related deaths (1.6%) compared to rCOJEC (7.1%) and NB84 (7.5%) (p = 0.037). On multivariate analysis LDH (p = 0.023), ferritin (p = 0.002) and INSS stage (p = 0.006) were identified as significant prognostic factors for OS. The induction chemotherapy was not significant for OS (p = 0.18), but significant for EFS (p = 0.08) Treatment with NB84 achieved better mCR, OS and EFS, while OPEC/OJEC had the least treatment-related deaths. In resource-constrained settings, OPEC/OJEC is advised as induction chemotherapy in HR-NB due to less toxicity as reflected in less treatment-related deaths. | en_ZA |
dc.description.department | Paediatrics and Child Health | en_ZA |
dc.description.embargo | 2021-02-19 | |
dc.description.librarian | hj2020 | en_ZA |
dc.description.sponsorship | Kinderkankerfonds, Belgium | en_ZA |
dc.description.uri | https://www.tandfonline.com/loi/ipho20 | en_ZA |
dc.identifier.citation | Jaques Van Heerden, Jennifer Geel, Marc Hendricks, Kristien Wouters, Ané Büchner, Gita Naidu, G. P. Hadley, Jan Du Plessis, Barry Van Emmenes, Anel Van Zyl, Johani Vermeulen & Mariana Kruger (2020): The evaluation of induction chemotherapy regimens for high-risk neuroblastoma in South African children, Pediatric Hematology and Oncology 37(4): 300-313, DOI: 10.1080/08880018.2020.1717698. | en_ZA |
dc.identifier.issn | 0888-0018 (print) | |
dc.identifier.issn | 1521-0669 (online) | |
dc.identifier.other | 10.1080/08880018.2020.1717698 | |
dc.identifier.uri | http://hdl.handle.net/2263/74732 | |
dc.language.iso | en | en_ZA |
dc.publisher | Taylor and Francis | en_ZA |
dc.rights | © 2020 Taylor & Francis Group, LLC. This is an electronic version of an article published in Pediatric Hematology and Oncology, vol. 37, no. 4, pp. 300-313, 2020. doi : 10.1080/08880018.2020.1717698. Pediatric Hematology and Oncology is available online at : https://www.tandfonline.com/loi/ipho20. | en_ZA |
dc.subject | High risk | en_ZA |
dc.subject | Induction chemotherapy | en_ZA |
dc.subject | Neuroblastoma | en_ZA |
dc.subject | South Africa (SA) | en_ZA |
dc.title | The evaluation of induction chemotherapy regimens for high-risk neuroblastoma in South African children | en_ZA |
dc.type | Postprint Article | en_ZA |