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| dc.contributor.author | Le Roux, Jannie
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| dc.contributor.author | Rubow, Sietke
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| dc.contributor.author | Ebenhan, Thomas
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| dc.contributor.author | Wagener, Carl
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| dc.date.accessioned | 2020-03-26T07:38:08Z | |
| dc.date.issued | 2020-01 | |
| dc.description.abstract | Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [68Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [68Ga]Ga-NOTA-UBI for clinical infection imaging. | en_ZA |
| dc.description.department | Nuclear Medicine | en_ZA |
| dc.description.embargo | 2020-11-01 | |
| dc.description.librarian | hj2020 | en_ZA |
| dc.description.sponsorship | Africa- X-ray Industrial and Medical (AXIM) | en_ZA |
| dc.description.uri | http://link.springer.com/journal/10967 | en_ZA |
| dc.identifier.citation | Le Roux, J., Rubow, S., Ebenhan, T. et al. An automated synthesis method for 68Ga-labelled ubiquicidin 29–41. Journal of Radioanalytical and Nuclear Chemistry 323, 105–116 (2020). https://doi.org/10.1007/s10967-019-06910-1. | en_ZA |
| dc.identifier.issn | 0236-5731 (print) | |
| dc.identifier.issn | 1588-2780 (online) | |
| dc.identifier.other | 10.1007/s10967-019-06910-1 | |
| dc.identifier.uri | http://hdl.handle.net/2263/73836 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | Springer | en_ZA |
| dc.rights | © Akadémiai Kiadó, Budapest, Hungary 2010. The original publication is available at : http://link.springer.comjournal/10967. | en_ZA |
| dc.subject | Automated synthesis | en_ZA |
| dc.subject | Ubiquicidin | en_ZA |
| dc.subject | NOTA-UBI | en_ZA |
| dc.subject | 68Ga NOTA-UBI | en_ZA |
| dc.subject | Good manufacturing practice | en_ZA |
| dc.subject | Radiolabelling | en_ZA |
| dc.title | An automated synthesis method for 68Ga-labelled ubiquicidin 29–41 | en_ZA |
| dc.type | Postprint Article | en_ZA |
