An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

Show simple item record Le Roux, Jannie Rubow, Sietke Ebenhan, Thomas Wagener, Carl 2020-03-26T07:38:08Z 2020-01
dc.description.abstract Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [68Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [68Ga]Ga-NOTA-UBI for clinical infection imaging. en_ZA
dc.description.department Nuclear Medicine en_ZA
dc.description.embargo 2020-11-01
dc.description.librarian hj2020 en_ZA
dc.description.sponsorship Africa- X-ray Industrial and Medical (AXIM) en_ZA
dc.description.uri en_ZA
dc.identifier.citation Le Roux, J., Rubow, S., Ebenhan, T. et al. An automated synthesis method for 68Ga-labelled ubiquicidin 29–41. Journal of Radioanalytical and Nuclear Chemistry 323, 105–116 (2020). en_ZA
dc.identifier.issn 0236-5731 (print)
dc.identifier.issn 1588-2780 (online)
dc.identifier.other 10.1007/s10967-019-06910-1
dc.language.iso en en_ZA
dc.publisher Springer en_ZA
dc.rights © Akadémiai Kiadó, Budapest, Hungary 2010. The original publication is available at : http://link.springer.comjournal/10967. en_ZA
dc.subject Automated synthesis en_ZA
dc.subject Ubiquicidin en_ZA
dc.subject NOTA-UBI en_ZA
dc.subject 68Ga NOTA-UBI en_ZA
dc.subject Good manufacturing practice en_ZA
dc.subject Radiolabelling en_ZA
dc.title An automated synthesis method for 68Ga-labelled ubiquicidin 29–41 en_ZA
dc.type Postprint Article en_ZA

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