An automated synthesis method for 68Ga-labelled ubiquicidin 29–41
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Date
Authors
Le Roux, Jannie
Rubow, Sietke
Ebenhan, Thomas
Wagener, Carl
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [68Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [68Ga]Ga-NOTA-UBI for clinical infection imaging.
Description
Keywords
Automated synthesis, Ubiquicidin, NOTA-UBI, 68Ga NOTA-UBI, Good manufacturing practice, Radiolabelling
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Citation
Le Roux, J., Rubow, S., Ebenhan, T. et al. An automated synthesis method for 68Ga-labelled ubiquicidin 29–41. Journal of Radioanalytical and Nuclear Chemistry 323, 105–116 (2020). https://doi.org/10.1007/s10967-019-06910-1.