An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

dc.contributor.authorLe Roux, Jannie
dc.contributor.authorRubow, Sietke
dc.contributor.authorEbenhan, Thomas
dc.contributor.authorWagener, Carl
dc.date.accessioned2020-03-26T07:38:08Z
dc.date.issued2020-01
dc.description.abstractPublished methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [68Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [68Ga]Ga-NOTA-UBI for clinical infection imaging.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.embargo2020-11-01
dc.description.librarianhj2020en_ZA
dc.description.sponsorshipAfrica- X-ray Industrial and Medical (AXIM)en_ZA
dc.description.urihttp://link.springer.com/journal/10967en_ZA
dc.identifier.citationLe Roux, J., Rubow, S., Ebenhan, T. et al. An automated synthesis method for 68Ga-labelled ubiquicidin 29–41. Journal of Radioanalytical and Nuclear Chemistry 323, 105–116 (2020). https://doi.org/10.1007/s10967-019-06910-1.en_ZA
dc.identifier.issn0236-5731 (print)
dc.identifier.issn1588-2780 (online)
dc.identifier.other10.1007/s10967-019-06910-1
dc.identifier.urihttp://hdl.handle.net/2263/73836
dc.language.isoenen_ZA
dc.publisherSpringeren_ZA
dc.rights© Akadémiai Kiadó, Budapest, Hungary 2010. The original publication is available at : http://link.springer.comjournal/10967.en_ZA
dc.subjectAutomated synthesisen_ZA
dc.subjectUbiquicidinen_ZA
dc.subjectNOTA-UBIen_ZA
dc.subject68Ga NOTA-UBIen_ZA
dc.subjectGood manufacturing practiceen_ZA
dc.subjectRadiolabellingen_ZA
dc.titleAn automated synthesis method for 68Ga-labelled ubiquicidin 29–41en_ZA
dc.typePostprint Articleen_ZA

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