Evidence of intragenic recombination in African horse sickness virus

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dc.contributor.author Ngoveni, Harry G.
dc.contributor.author Van Schalkwyk, Antoinette
dc.contributor.author Koekemoer, J.J.O. (Otto)
dc.date.accessioned 2019-12-02T06:14:52Z
dc.date.available 2019-12-02T06:14:52Z
dc.date.issued 2019-07-18
dc.description.abstract Intragenic recombination has been described in various RNA viruses as a mechanism to increase genetic diversity, resulting in increased virulence, expanded host range, or adaptability to a changing environment. Orbiviruses are no exception to this, with intragenic recombination previously detected in the type species, bluetongue virus (BTV). African horse sickness virus (AHSV) is a double-stranded RNA virus belonging to the Oribivirus genus in the family Reoviridae. Genetic recombination through reassortment has been described inAHSV, but not through homologous intragenic recombination. The influence of the latter on the evolution of AHSV was investigated by analyzing the complete genomes of more than 100 viruses to identify evidence of recombination. Segment-1, segment-6, segment-7, and segment-10 showed evidence of intragenic recombination, yet only one (Segment-10) of these events was manifested in subsequent lineages. The other three hybrid segments were as a result of recombination between field isolates and the vaccine derived live attenuated viruses (ALVs). en_ZA
dc.description.department Veterinary Tropical Diseases en_ZA
dc.description.librarian am2019 en_ZA
dc.description.sponsorship The Economic Competitive Support Package (ECSP) from National Treasury of the South African Government. en_ZA
dc.description.uri http://www.mdpi.com/journal/viruses en_ZA
dc.identifier.citation Ngoveni, H.G., Schalkwyk, A. & Koekemoer, J.J.O. 2019, 'Evidence of intragenic recombination in African horse sickness virus', Viruses, vol. 11, art. 654, pp. 1-15. en_ZA
dc.identifier.issn 1999-4915
dc.identifier.other 10.3390/v11070654
dc.identifier.uri http://hdl.handle.net/2263/72446
dc.language.iso en en_ZA
dc.publisher MDPI Publishing en_ZA
dc.rights © 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. en_ZA
dc.subject Orbivirus genome en_ZA
dc.subject Virus recombination en_ZA
dc.subject African horse sickness virus (AHSV) en_ZA
dc.subject RNA viruses en_ZA
dc.subject dsRNA virus en_ZA
dc.subject Serotypes en_ZA
dc.subject Expression en_ZA
dc.subject Mechanism en_ZA
dc.subject Identification en_ZA
dc.subject Protein en_ZA
dc.subject South Africa (SA) en_ZA
dc.subject Phylogenetic analysis en_ZA
dc.subject Bluetongue virus (BTV) en_ZA
dc.title Evidence of intragenic recombination in African horse sickness virus en_ZA
dc.type Article en_ZA


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