Evidence of intragenic recombination in African horse sickness virus

dc.contributor.authorNgoveni, Harry G.
dc.contributor.authorVan Schalkwyk, Antoinette
dc.contributor.authorKoekemoer, J.J.O. (Otto)
dc.date.accessioned2019-12-02T06:14:52Z
dc.date.available2019-12-02T06:14:52Z
dc.date.issued2019-07-18
dc.description.abstractIntragenic recombination has been described in various RNA viruses as a mechanism to increase genetic diversity, resulting in increased virulence, expanded host range, or adaptability to a changing environment. Orbiviruses are no exception to this, with intragenic recombination previously detected in the type species, bluetongue virus (BTV). African horse sickness virus (AHSV) is a double-stranded RNA virus belonging to the Oribivirus genus in the family Reoviridae. Genetic recombination through reassortment has been described inAHSV, but not through homologous intragenic recombination. The influence of the latter on the evolution of AHSV was investigated by analyzing the complete genomes of more than 100 viruses to identify evidence of recombination. Segment-1, segment-6, segment-7, and segment-10 showed evidence of intragenic recombination, yet only one (Segment-10) of these events was manifested in subsequent lineages. The other three hybrid segments were as a result of recombination between field isolates and the vaccine derived live attenuated viruses (ALVs).en_ZA
dc.description.departmentVeterinary Tropical Diseasesen_ZA
dc.description.librarianam2019en_ZA
dc.description.sponsorshipThe Economic Competitive Support Package (ECSP) from National Treasury of the South African Government.en_ZA
dc.description.urihttp://www.mdpi.com/journal/virusesen_ZA
dc.identifier.citationNgoveni, H.G., Schalkwyk, A. & Koekemoer, J.J.O. 2019, 'Evidence of intragenic recombination in African horse sickness virus', Viruses, vol. 11, art. 654, pp. 1-15.en_ZA
dc.identifier.issn1999-4915
dc.identifier.other10.3390/v11070654
dc.identifier.urihttp://hdl.handle.net/2263/72446
dc.language.isoenen_ZA
dc.publisherMDPI Publishingen_ZA
dc.rights© 2019 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_ZA
dc.subjectOrbivirus genomeen_ZA
dc.subjectVirus recombinationen_ZA
dc.subjectAfrican horse sickness virus (AHSV)en_ZA
dc.subjectRNA virusesen_ZA
dc.subjectdsRNA virusen_ZA
dc.subjectSerotypesen_ZA
dc.subjectExpressionen_ZA
dc.subjectMechanismen_ZA
dc.subjectIdentificationen_ZA
dc.subjectProteinen_ZA
dc.subjectSouth Africa (SA)en_ZA
dc.subjectPhylogenetic analysisen_ZA
dc.subjectBluetongue virus (BTV)en_ZA
dc.titleEvidence of intragenic recombination in African horse sickness virusen_ZA
dc.typeArticleen_ZA

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