Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa

Show simple item record

dc.contributor.author Wright, C.Y. (Caradee)
dc.contributor.author Lucas, Robyn M.
dc.contributor.author D'Este, Catherine
dc.contributor.author Kapwata, Thandi
dc.contributor.author Kunene, Zamantimande
dc.contributor.author Swaminathan, Ashwin
dc.contributor.author Mathee, Angela
dc.contributor.author Albers, P.N. (Patricia Nicole)
dc.date.accessioned 2019-10-03T10:14:23Z
dc.date.issued 2019-01
dc.description.abstract The incidence of many serious childhood infections can be reduced by vaccination. High sun exposure at the time of vaccination has been associated with a reduced antigen‐specific immune response. We hypothesized that providing sun protection advice and equipment to mothers of children who were waiting to be vaccinated would result in a more robust immunization response. We conducted a pilot study in 2015/2016 (data analyzed in 2017–2018) among 98 Black African children (~18 months of age) receiving the booster measles vaccination at two clinics in South Africa. Clinics were randomized to receive (or not) sun protection advice and equipment. We recorded demographic information on children and mothers and data on the child's usual sun exposure. At approximately 4 weeks’ postmeasles vaccination, we measured measles immunoglobulin G levels in children. All children with blood results (n = 87, 89%) across both groups had antibody titers higher than 200 mIU mL−1 which was considered the protective antibody concentration. There was no statistically significant difference in titers between groups: geometric difference in mean titers 1.13 mIU mL−1 (95% CI 0.85, 1.51; P = 0.39) and 1.38 mIU mL−1 (95% CI 0.90, 2.11, P = 0.14) for unadjusted and adjusted analyses, respectively. This study demonstrated that a sun protection intervention study could be performed in a developing‐world pediatric vaccination setting. Although the sun protection intervention around the time of vaccination was not associated with a higher antibody level, given the potential importance of such an effect, a larger study should be considered. en_ZA
dc.description.department Geography, Geoinformatics and Meteorology en_ZA
dc.description.embargo 2020-01-01
dc.description.librarian hj2019 en_ZA
dc.description.sponsorship The National Research Foundation (NRF) of South Africa (Grant number: 93426) and the South African Medical Research Council (SAMRC) Heat and Health Flagship Seed project. en_ZA
dc.description.uri https://onlinelibrary.wiley.com/journal/17511097 en_ZA
dc.identifier.citation Wright, C.Y., Lucas, R.M., D'Este, C. et al. 2019, 'Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa', Photochemistry and Photobiology, vol. 95, no. 1, pp. 446-452. en_ZA
dc.identifier.issn 0031-8655 (print)
dc.identifier.issn 1751-1097 (online)
dc.identifier.other 10.1111/php.13004
dc.identifier.uri http://hdl.handle.net/2263/71566
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2018 The American Society of Photobiology. This is the pre-peer reviewed version of the following article : 'Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa', Photochemistry and Photobiology, vol. 95, no. 1, pp. 446-452, 2019, doi : 10.1111/php.13004. The definite version is available at : https://onlinelibrary.wiley.com/journal/17511097. en_ZA
dc.subject Ultraviolet (UV) en_ZA
dc.subject Ultraviolet radiation en_ZA
dc.subject Children en_ZA
dc.subject Susceptibility en_ZA
dc.subject Antibody en_ZA
dc.subject Rural South Africa en_ZA
dc.subject Vaccination en_ZA
dc.title Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa en_ZA
dc.type Postprint Article en_ZA


Files in this item

This item appears in the following Collection(s)

Show simple item record