Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa

dc.contributor.authorWright, Caradee Yael
dc.contributor.authorLucas, Robyn M.
dc.contributor.authorD'Este, Catherine
dc.contributor.authorKapwata, Thandi
dc.contributor.authorKunene, Zamantimande
dc.contributor.authorSwaminathan, Ashwin
dc.contributor.authorMathee, Angela
dc.contributor.authorAlbers, P.N. (Patricia Nicole)
dc.date.accessioned2019-10-03T10:14:23Z
dc.date.issued2019-01
dc.description.abstractThe incidence of many serious childhood infections can be reduced by vaccination. High sun exposure at the time of vaccination has been associated with a reduced antigen‐specific immune response. We hypothesized that providing sun protection advice and equipment to mothers of children who were waiting to be vaccinated would result in a more robust immunization response. We conducted a pilot study in 2015/2016 (data analyzed in 2017–2018) among 98 Black African children (~18 months of age) receiving the booster measles vaccination at two clinics in South Africa. Clinics were randomized to receive (or not) sun protection advice and equipment. We recorded demographic information on children and mothers and data on the child's usual sun exposure. At approximately 4 weeks’ postmeasles vaccination, we measured measles immunoglobulin G levels in children. All children with blood results (n = 87, 89%) across both groups had antibody titers higher than 200 mIU mL−1 which was considered the protective antibody concentration. There was no statistically significant difference in titers between groups: geometric difference in mean titers 1.13 mIU mL−1 (95% CI 0.85, 1.51; P = 0.39) and 1.38 mIU mL−1 (95% CI 0.90, 2.11, P = 0.14) for unadjusted and adjusted analyses, respectively. This study demonstrated that a sun protection intervention study could be performed in a developing‐world pediatric vaccination setting. Although the sun protection intervention around the time of vaccination was not associated with a higher antibody level, given the potential importance of such an effect, a larger study should be considered.en_ZA
dc.description.departmentGeography, Geoinformatics and Meteorologyen_ZA
dc.description.embargo2020-01-01
dc.description.librarianhj2019en_ZA
dc.description.sponsorshipThe National Research Foundation (NRF) of South Africa (Grant number: 93426) and the South African Medical Research Council (SAMRC) Heat and Health Flagship Seed project.en_ZA
dc.description.urihttps://onlinelibrary.wiley.com/journal/17511097en_ZA
dc.identifier.citationWright, C.Y., Lucas, R.M., D'Este, C. et al. 2019, 'Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa', Photochemistry and Photobiology, vol. 95, no. 1, pp. 446-452.en_ZA
dc.identifier.issn0031-8655 (print)
dc.identifier.issn1751-1097 (online)
dc.identifier.other10.1111/php.13004
dc.identifier.urihttp://hdl.handle.net/2263/71566
dc.language.isoenen_ZA
dc.publisherWileyen_ZA
dc.rights© 2018 The American Society of Photobiology. This is the pre-peer reviewed version of the following article : 'Effect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africa', Photochemistry and Photobiology, vol. 95, no. 1, pp. 446-452, 2019, doi : 10.1111/php.13004. The definite version is available at : https://onlinelibrary.wiley.com/journal/17511097.en_ZA
dc.subjectUltraviolet (UV)en_ZA
dc.subjectUltraviolet radiationen_ZA
dc.subjectChildrenen_ZA
dc.subjectSusceptibilityen_ZA
dc.subjectAntibodyen_ZA
dc.subjectRural South Africaen_ZA
dc.subjectVaccinationen_ZA
dc.titleEffect of a sun protection intervention on the immune response to measles booster vaccination in infants in rural South Africaen_ZA
dc.typePostprint Articleen_ZA

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