Adolescent access to care and risk of early mother-to-child HIV transmission

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Authors

Ramraj, Trisha
Jackson, Debra
Dinh, Thu-Ha
Olorunju, Steve
Lombard, Carl
Sherman, Gayle
Puren, Adrian
Ramokolo, Vundli
Noveve, Nobuntu
Singh, Yages

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

PURPOSE : Adolescent females aged 15–19 account for 62% of new HIV infections and give birth to 16 million infants annually. We quantify the risk of early mother-to-child transmission (MTCT) of HIV among adolescents enrolled in nationally representative MTCT surveillance studies in South Africa. METHODS : Data from 4,814 adolescent (≤19 years) and 25,453 adult (≥20 years) mothers and their infants aged 4–8 weeks were analyzed. These data were gathered during three nationally representative, cross-sectional, facility-based surveys, conducted in 2010, 2011–2012, and 2012– 2013. All infants were tested for HIV antibody (enzyme immunoassay), to determine HIV exposure. Enzyme immunoassay-positive infants or those born to self-reported HIV-positive mothers were tested for HIV infection (total nucleic acid polymerase chain reaction). Maternal HIV positivity was inferred from infant HIV antibody positivity. All analyses were weighted for sample realization and population live births.

Description

These data were presented as an oral presentation at the 7th South African AIDS Conference in Durban, 2015, and was accepted as a poster at the 8th International AIDS Society Conference in Vancouver in 2015.

Keywords

Mother-to-child transmission (MTCT), Human immunodeficiency virus (HIV), South Africa (SA), Adolescent females

Sustainable Development Goals

Citation

Ramraj, T., Jackson, D., Dinh, T.H. et al. 2018, 'Adolescent access to care and risk of early mother-to-child HIV transmission', Journal of Adolescent Health, vol. 62, no. 4, pp. 434-443.