The occurrence of dermatosparaxis in a commercial Drakensberger cattle herd in South Africa

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dc.contributor.author Holm, D.E. (Dietmar Erik)
dc.contributor.author Van Wilpe, Erna
dc.contributor.author Harper, Cindy Kim
dc.contributor.author Duncan, N.M. (Neil)
dc.coverage.spatial Africa en
dc.coverage.spatial South Africa en
dc.date.accessioned 2008-09-01T06:35:05Z
dc.date.available 2008-09-01T06:35:05Z
dc.date.issued 2008-03
dc.description.abstract Dermatosparaxis is a heritable collagen dysplasia causing skin extensibility and fragility. In Belgian Blue cattle this mutation has been described as a 3 base pair (bp) change followed by a 17 bp deletion in the gene coding for procollagen 1 N-Proteinase (pNPI). An outbreak in a commercial Drakensberger herd in South Africa followed the introduction in late 2000 of a 3-year-old bull that developed skin lesions in 2001 and was culled in 2002. Some of his offspring were similarly affected, 1 of which was kept as a breeding bull after his sire's death. Two affected calves were referred to the Onderstepoort Veterinary Academic Hospital in October 2005. Detailed examination revealed only skin abnormalities limited to the lateral extremities of the thorax, abdomen and pelvis, viz. either acute lacerations of varying sizes, slow healing defects or thin scars in chronic cases. During a subsequent farm visit, 13 animals with similar wounds were seen in the herd of 146 animals. Electron microscopic examination of skin biopsies revealed haphazard arrangement and loose packing of dermal collagen fibrils within collagen fibres. The fibrils showed size variation and slightly irregular outlines on cross-section, consistent with mild dermatosparaxis. DNA samples of affected calves were analysed using primers designed to amplify the region of the pNPI gene that contained the mutation described in Belgian Blue cattle, but this mutation could not be demonstrated in any of the animals tested. It is concluded that a form of dermatosparaxis with a different gene mutation from that described in Belgian Blue cattle exists in Drakensberger cattle in South Africa. This possibly also explains the milder and more delayed clinical signs and the milder dermal collagen ultrastructural abnormalities. en
dc.format.extent 418081 bytes
dc.format.extent 6 p. : ill. (some col.)
dc.format.mimetype application/pdf
dc.identifier.citation Holm, DE, Van Wilpe, E, Harper, CK & Duncan NM 2008, 'The occurrence of dermatosparaxis in a commercial Drakensberger cattle herd in South Africa', Journal of the South African Veterinary Association, vol. 79, no. 1, pp. 19-24. [http://www.journals.co.za/ej/ejour_savet.html] en
dc.identifier.issn 0038-2809
dc.identifier.uri http://hdl.handle.net/2263/6802
dc.language.iso en en
dc.publisher South African Veterinary Association en
dc.rights South African Veterinary Association en
dc.subject Cattle en
dc.subject Collagen en
dc.subject Dermatosparaxis en
dc.subject Drakensberger en
dc.subject Heritable en
dc.subject South Africa en
dc.subject Ultrastructure en
dc.subject.lcsh Cattle -- Diseases -- South Africa en
dc.subject.lcsh Veterinary dermatology -- South Africa en
dc.title The occurrence of dermatosparaxis in a commercial Drakensberger cattle herd in South Africa en
dc.type Article en


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