Meta-analyses of the sensitivity and specificity of ante-mortem andpost-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland

Show simple item record Nunez-Garcia, Javier Downs, Sara H. Parry, Jessica E. Abernethy, D.A. (Darrell) Broughan, Jennifer M. Cameron, Angus R. Cook, Alasdair J. De la Rua-Domenech, Ricardo Goodchild, Anthony V. Gunn, Jane More, Simon J. Watson, Eamon Welsh, Michael Whelan, Adam O. Woolliams, John A. Clifton-Hadley, Richard S. Greiner, Matthias 2018-09-07T08:08:38Z 2018-09-07T08:08:38Z 2018-05
dc.description Appendix A. Supplementary data : Summary tables and graphs for the sensitivity and specificity from the meta-analysis for different diagnostic tests and a description of the search for additional references conducted in 2015 are provided in the supplementary material. en_ZA
dc.description.abstract Bovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accurate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was, through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 different ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic review of the scientific literature (published 1934-2009) diagnostic Se and Sp were estimated using Bayesian logistic regression models adjusting for confounding factors. Random effect terms were used to account for unexplained heterogeneity. Parameters in the models were implemented using Markov Chain Monte Carlo (MCMC), and posterior distributions for the diagnostic parameters with adjustment for covariates (confounding factors) were obtained using the inverse logit function. Estimates for Se and/or Sp of the tuberculin skin tests and the IFN-γ blood test were compared with estimates published 2010-2015. Median Se for the single intradermal comparative cervical tuberculin skin (SICCT) test (standard interpretation) was 0.50 and Bayesian credible intervals (CrI) were wide (95% CrI 0.26, 0.78). Median Sp for the SICCT test was 1.00 (95% CrI 0.99, 1.00). Estimates for the IFN-γ blood test Bovine Purified Protein Derivative (PPD)-Avian PPD and Early Secreted Antigen target 6 and Culture Filtrate Protein 10 (ESAT-6/CFP10) ESAT6/CFP10 were 0.67 (95% CrI 0.49, 0.82) and 0.78 (95% CrI 0.60, 0.90) respectively for Se, and 0.98 (95% CrI 0.96, 0.99) and 0.99 (95% CrI 0.99, 1.00) for Sp. The study provides an overview of the accuracy of a range of contemporary diagnostic tests for bTB in cattle. Better understanding of diagnostic test performance is essential for the design of effective control strategies and their evaluation. en_ZA
dc.description.department Veterinary Tropical Diseases en_ZA
dc.description.librarian am2018 en_ZA
dc.description.sponsorship The SE3238 project “Meta-analysis of diagnostic tests and modelling to identify appropriate testing strategies to reduce M. bovis infection in GB herds” was funded by the UK Department for Environment, Food and Rural Affairs (Defra). en_ZA
dc.description.uri http: // en_ZA
dc.identifier.citation Nunez-Garcia, J., Downs, S.H., Parry, J.E. et al. 2018, 'Meta-analyses of the sensitivity and specificity of ante-mortem andpost-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland', Preventive Veterinary Medicine, vol. 153, pp. 94-107. en_ZA
dc.identifier.issn 0167-5877 (print)
dc.identifier.other 1873-1716 (online)
dc.identifier.other 10.1016/j.prevetmed.2017.02.017
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2017 Published by Elsevier B.V. This is an open access article under the Open Government License (OGL) ( en_ZA
dc.subject Diagnostic tests en_ZA
dc.subject Meta-analysis en_ZA
dc.subject Performance en_ZA
dc.subject Sensitivity en_ZA
dc.subject Specificity en_ZA
dc.subject Bovine tuberculosis (bTB) en_ZA
dc.subject Single intradermal comparative cervical tuberculin skin (SICCT) en_ZA
dc.subject Gamma interferon assay en_ZA
dc.subject Mycobacterium bovis en_ZA
dc.subject Skin test en_ZA
dc.subject Immune response en_ZA
dc.subject Disease en_ZA
dc.subject Accuracy en_ZA
dc.subject Risk factors en_ZA
dc.subject Milk samples en_ZA
dc.subject Infected cattle en_ZA
dc.subject Great Britain (GB) en_ZA
dc.title Meta-analyses of the sensitivity and specificity of ante-mortem andpost-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland en_ZA
dc.type Article en_ZA

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