dc.contributor.author |
Tshabalala, Mqondisi
|
|
dc.contributor.author |
Ingram, Charlotte
|
|
dc.contributor.author |
Schlaphoff, Terry
|
|
dc.contributor.author |
Borrill, Veronica
|
|
dc.contributor.author |
Christoffels, Alan
|
|
dc.contributor.author |
Pepper, Michael Sean
|
|
dc.date.accessioned |
2018-06-28T12:23:44Z |
|
dc.date.available |
2018-06-28T12:23:44Z |
|
dc.date.issued |
2018-04-23 |
|
dc.description |
Supplementary Table 1 : HLA-A, HLA-B, HLA-C,
HLA-DRB1, and HLA-DQB1 allele frequencies in 237 volunteer
bone marrow donors registered in the South African Bone Marrow Registry. The 237 individuals described herein
are a subset of all SABMR registered donors. |
en_ZA |
dc.description |
Supplementary Table 2 : Two, three, four, and five loci Haplo-o-
Mat [38] estimated haplotype frequencies in 237 volunteer
bone marrow donors registered in the South African Bone
Marrow Registry. The 237 individuals described herein are
a subset of all SABMR registered donors. |
en_ZA |
dc.description.abstract |
Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, andHLA-DQB1allele and haplotype frequencies were studied in
a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software
was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele
code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are
reported. The most frequent alleles were A∗ 02:02g (0.096), B ∗ 07:02g (0.082), C∗ 07:02g (0.180), DQB1∗ 06:02 (0.157), and
DRB1 ∗ 15:01 (0.072). The most common haplotype was A∗ 03:01g~B ∗ 07:02g~C∗ 07:02g~DQB1∗ 06:02~DRB1∗ 15:01
(0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A,
B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype
frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the
sample size was small, our results form a key resource for future population studies, disease association studies, and donor
recruitment strategies. |
en_ZA |
dc.description.department |
Immunology |
en_ZA |
dc.description.librarian |
am2018 |
en_ZA |
dc.description.sponsorship |
The South Africa Medical Research Council (SAMRC) in terms of the MRC's Flagships Awards Project SAMRC-RFA-UFSP-01-2013/STEM CELLS, the SAMRC Extramural Unit for Stem Cell Research and Therapy, the Institute for Cellular and Molecular Medicine of the University of Pretoria, and the National Research Foundation of South Africa. |
en_ZA |
dc.description.uri |
http://www.hindawi.com/journals/jir |
en_ZA |
dc.identifier.citation |
Tshabalala, M., Ingram, C., Schlaphoff, T. et al. 2018, 'Human leukocyte antigen-A, B, C, DRB1, and DQB1 allele and haplotype frequencies in a subset of 237 donors in the South African bone marrow registry', Journal of Immunology Research, vol. 2018, art. no. 2031571, pp. 1-8. |
en_ZA |
dc.identifier.issn |
2314-8861 (print) |
|
dc.identifier.issn |
2314-7156 (online) |
|
dc.identifier.other |
10.1155/2018/2031571 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/65254 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Hindawi Publishing |
en_ZA |
dc.rights |
© 2018 Mqondisi Tshabalala et al. This is an open access article distributed under the Creative Commons Attribution
License |
en_ZA |
dc.subject |
Donor recruitment strategies |
en_ZA |
dc.subject |
Allele |
en_ZA |
dc.subject |
Human leukocyte antigen (HLA) |
en_ZA |
dc.subject |
Multiple allele code (MAC) |
en_ZA |
dc.subject |
Stem cell donors |
en_ZA |
dc.subject |
Class-I molecule |
en_ZA |
dc.subject |
Diversity |
en_ZA |
dc.subject |
Transplantation |
en_ZA |
dc.subject |
Population |
en_ZA |
dc.subject |
Challenges |
en_ZA |
dc.subject |
Recruitment |
en_ZA |
dc.subject |
Algorithm |
en_ZA |
dc.subject |
South African Medical Research Council (SAMRC) |
en_ZA |
dc.title |
Human leukocyte antigen-A, B, C, DRB1, and DQB1 allele and haplotype frequencies in a subset of 237 donors in the South African bone marrow registry |
en_ZA |
dc.type |
Article |
en_ZA |