Human leukocyte antigen-A, B, C, DRB1, and DQB1 allele and haplotype frequencies in a subset of 237 donors in the South African bone marrow registry

dc.contributor.authorTshabalala, Mqondisi
dc.contributor.authorIngram, Charlotte
dc.contributor.authorSchlaphoff, Terry
dc.contributor.authorBorrill, Veronica
dc.contributor.authorChristoffels, Alan
dc.contributor.authorPepper, Michael Sean
dc.date.accessioned2018-06-28T12:23:44Z
dc.date.available2018-06-28T12:23:44Z
dc.date.issued2018-04-23
dc.descriptionSupplementary Table 1 : HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele frequencies in 237 volunteer bone marrow donors registered in the South African Bone Marrow Registry. The 237 individuals described herein are a subset of all SABMR registered donors.en_ZA
dc.descriptionSupplementary Table 2 : Two, three, four, and five loci Haplo-o- Mat [38] estimated haplotype frequencies in 237 volunteer bone marrow donors registered in the South African Bone Marrow Registry. The 237 individuals described herein are a subset of all SABMR registered donors.en_ZA
dc.description.abstractHuman leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, andHLA-DQB1allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are reported. The most frequent alleles were A∗ 02:02g (0.096), B ∗ 07:02g (0.082), C∗ 07:02g (0.180), DQB1∗ 06:02 (0.157), and DRB1 ∗ 15:01 (0.072). The most common haplotype was A∗ 03:01g~B ∗ 07:02g~C∗ 07:02g~DQB1∗ 06:02~DRB1∗ 15:01 (0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A, B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the sample size was small, our results form a key resource for future population studies, disease association studies, and donor recruitment strategies.en_ZA
dc.description.departmentImmunologyen_ZA
dc.description.librarianam2018en_ZA
dc.description.sponsorshipThe South Africa Medical Research Council (SAMRC) in terms of the MRC's Flagships Awards Project SAMRC-RFA-UFSP-01-2013/STEM CELLS, the SAMRC Extramural Unit for Stem Cell Research and Therapy, the Institute for Cellular and Molecular Medicine of the University of Pretoria, and the National Research Foundation of South Africa.en_ZA
dc.description.urihttp://www.hindawi.com/journals/jiren_ZA
dc.identifier.citationTshabalala, M., Ingram, C., Schlaphoff, T. et al. 2018, 'Human leukocyte antigen-A, B, C, DRB1, and DQB1 allele and haplotype frequencies in a subset of 237 donors in the South African bone marrow registry', Journal of Immunology Research, vol. 2018, art. no. 2031571, pp. 1-8.en_ZA
dc.identifier.issn2314-8861 (print)
dc.identifier.issn2314-7156 (online)
dc.identifier.other10.1155/2018/2031571
dc.identifier.urihttp://hdl.handle.net/2263/65254
dc.language.isoenen_ZA
dc.publisherHindawi Publishingen_ZA
dc.rights© 2018 Mqondisi Tshabalala et al. This is an open access article distributed under the Creative Commons Attribution Licenseen_ZA
dc.subjectDonor recruitment strategiesen_ZA
dc.subjectAlleleen_ZA
dc.subjectHuman leukocyte antigen (HLA)en_ZA
dc.subjectMultiple allele code (MAC)en_ZA
dc.subjectStem cell donorsen_ZA
dc.subjectClass-I moleculeen_ZA
dc.subjectDiversityen_ZA
dc.subjectTransplantationen_ZA
dc.subjectPopulationen_ZA
dc.subjectChallengesen_ZA
dc.subjectRecruitmenten_ZA
dc.subjectAlgorithmen_ZA
dc.subjectSouth African Medical Research Council (SAMRC)en_ZA
dc.titleHuman leukocyte antigen-A, B, C, DRB1, and DQB1 allele and haplotype frequencies in a subset of 237 donors in the South African bone marrow registryen_ZA
dc.typeArticleen_ZA

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