Eryptosis : an erythrocyte’s suicidal type of cell death

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dc.contributor.author Repsold, Lisa
dc.contributor.author Joubert, Annie M.
dc.date.accessioned 2018-03-28T11:47:49Z
dc.date.available 2018-03-28T11:47:49Z
dc.date.issued 2018-01-03
dc.description.abstract Erythrocytes play an important role in oxygen and carbon dioxide transport. Although erythrocytes possess no nucleus or mitochondria, they fulfil severalmetabolic activities namely, the Embden-Meyerhof pathway, as well as the hexose monophosphate shunt. Metabolic processes within the erythrocyte contribute to the morphology/shape of the cell and important constituents are being kept in an active, reduced form. Erythrocytes undergo a form of suicidal cell death called eryptosis. Eryptosis results from a wide variety of contributors including hyperosmolarity, oxidative stress, and exposure to xenobiotics. Eryptosis occurs before the erythrocyte has had a chance to be naturally removed from the circulation after its 120-day lifespan and is characterised by the presence of membrane blebbing, cell shrinkage, and phosphatidylserine exposure that correspond to nucleated cell apoptotic characteristics. After eryptosis is triggered there is an increase in cytosolic calcium(Ca2+) ion levels.This increase causes activation of Ca2+-sensitive potassium (K+) channels which leads to a decrease in intracellular potassium chloride (KCl) and shrinkage of the erythrocyte. Ceramide, produced by sphingomyelinase from the cell membrane’s sphingomyelin, contributes to the occurrence of eryptosis. Eryptosis ensures healthy erythrocyte quantity in circulation whereas excessive eryptosismay set an environment for the clinical presence of pathophysiological conditions including anaemia. en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian am2018 en_ZA
dc.description.sponsorship The National Research Foundation, Struwig-Germeshuysen Research Trust, the Medical Research Council of South Africa, the Cancer Association of South Africa and the School of Medicine Research Committee of the Faculty of Health Sciences at the University of Pretoria. en_ZA
dc.identifier.citation Repsold, L. & Joubert, A.M. 2018, 'Eryptosis : an erythrocyte’s suicidal type of cell death', BioMed Research International, vol. 2018, art. no. ID 9405617, pp. 1-10. en_ZA
dc.identifier.issn 2314-6133 (print)
dc.identifier.issn 2314-6141 (online)
dc.identifier.other 10.1155/2018/9405617
dc.identifier.uri http://hdl.handle.net/2263/64339
dc.language.iso en en_ZA
dc.publisher Hindawi Publishing Corporation en_ZA
dc.rights © 2018 Lisa Repsold and Anna Margaretha Joubert. This is an open access article distributed under the Creative Commons Attribution License. en_ZA
dc.subject Erythrocytes en_ZA
dc.subject Anaemia en_ZA
dc.subject Eryptosis en_ZA
dc.subject Metabolic processes en_ZA
dc.subject Berghei infected mice en_ZA
dc.subject Red blood cells en_ZA
dc.subject Phosphatidylserine exposure en_ZA
dc.subject Hemolytic anemia en_ZA
dc.subject Cation channels en_ZA
dc.subject Plasmodium falciparum en_ZA
dc.subject Beta-thalassemia en_ZA
dc.subject Ion channels en_ZA
dc.subject Stimulation en_ZA
dc.subject Inhibition en_ZA
dc.title Eryptosis : an erythrocyte’s suicidal type of cell death en_ZA
dc.type Article en_ZA


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