Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009-2011

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Authors

Hellferscee, Orienka
Treurnicht, Florette K.
Tempia, Stefano
Variava, Ebrahim
Dawood, Halima
Kahn, Kathleen
Cohen, Adam L.
Pretorius, Marthi Andréa
Cohen, Cheryl
Madhi, Shabir A.

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Publisher

Wiley Open Access

Abstract

BACKGROUND : Human enteroviruses (EV) have been associated with severe acute respiratory illness (SARI) in South Africa. OBJECTIVES : We aimed to describe the molecular epidemiology of EV serotypes among patients hospitalized with SARI during 2009-2011. PATIENTS/METHODS : Study samples from patients were tested for the presence of enterovirus using a polymerase chain reaction assay. RESULTS : 8.2% (842/10 260) of SARI cases tested positive for enterovirus; 16% (7/45) were species EV-A, 44% (20/45) EV-B, 18% (8/45) EV-C and 22% (10/45) EV-D. Seventeen different EV serotypes were identified within EV-A to EV-D, of which EV-D68 (22%; 10/45) and Echovirus 3 (11%; 5/45) were the most prevalent. CONCLUSIONS : EV-D68 should be monitored in South Africa to assess the emergence of highly pathogenic strains.

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Keywords

Enterovirus, EV-D68, Pneumonia, South Africa (SA), Human enterovirus (HEV), Severe acute respiratory illness (SARI)

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Citation

Hellferscee O, Treurnicht FK, Tempia S, et al. Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011. Influenza Other Respi Viruses. 2017;11:211–219. https://DOI.org/10.1111/irv.12444,