Reconstructing prehistoric African population structure

Show simple item record Skoglund, Pontus Thompson, Jessica C. Prendergast, Mary E. Mittnik, Alissa Sirak, Kendra Hajdinjak, Mateja Salie, Tasneem Rohland, Nadin Mallick, Swapan Peltzer, Alexander Heinze, Anja Olalde, Iñigo Ferry, Matthew Harney, Eadaoin Michel, Megan Stewardson, Kristin Cerezo-Román, Jessica I. Chiumia, Chrissy Crowther, Alison Gomani-Chindebvu, Elizabeth Gidna, Agness O. Grillo, Katherine M. Helenius, I. Taneli Hellenthal, Garrett Helm, Richard Horton, Mark López, Saioa Mabulla, Audax Z.P. Parkington, John Shipton, Ceri Thomas, Mark G. Tibesasa, Ruth Welling, Menno Hayes, Vanessa M. Kennett, Douglas J. Ramesar, Raj Meyer, Matthias Pääbo, Svante Patterson, Nick Morris, Alan G. Boivin, Nicole Pinhasi, Ron Krause, Johannes Reich, David 2017-10-19T06:38:13Z 2017-09
dc.description.abstract We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers ∼8,100–2,500 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers ∼1,400 years ago. We document how the spread of farmers from western Africa involved complete replacement of local hunter-gatherers in some regions, and we track the spread of herders by showing that the population of a ∼3,100-year-old pastoralist from Tanzania contributed ancestry to people from northeastern to southern Africa, including a ∼1,200-year-old southern African pastoralist. The deepest diversifications of African lineages were complex, involving either repeated gene flow among geographically disparate groups or a lineage more deeply diverging than that of the San contributing more to some western African populations than to others. We finally leverage ancient genomes to document episodes of natural selection in southern African populations. en_ZA
dc.description.department Anthropology and Archaeology en_ZA
dc.description.department School of Health Systems and Public Health (SHSPH) en_ZA
dc.description.embargo 2018-09-21
dc.description.librarian hj2017 en_ZA
dc.description.sponsorship P.S. was supported by the Wenner-Gren Foundation and the Swedish Research Council (VR grant 2014-453). J.C.T was supported by a grant from the Program for the Enhancement of Research at Emory University. J.K. and A.M. were supported by the DFG grant KR 4015/1-1 and the Max Planck Society. K.Si. was supported by NSF grant BCS-1613577. M.Ha., A.H., M.Me., and S.P. were supported by the Max Planck Society. A.G.M. and J.P. were supported by the National Research Foundation of South Africa. R.R. was supported by the South African Medical Research Council. N.B. was supported by ERC starting grant SEALINKS (206148), and R.P. was supported by ERC starting grant ADNABIOARC (263441). M.G.T. was supported by Wellcome Trust Senior Investigator Award (grant number 100719/Z/12/Z). D.R. was supported by NIH grant GM100233 and by NSFHOMINID BCS-1032255 and is a Howard Hughes Medical Institute investigator. The laboratory at Penn State was supported by the NSF Archaeometry program (BCS-1460369, D.J.K.). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Skoglund, P., Thompson, J.C., Prendergast, M.E. ... et al. 2017, 'Reconstructing prehistoric African population structure', Cell, vol. 171, no. 1, pp. 59-71.e21. en_ZA
dc.identifier.issn 0092-8674 (print)
dc.identifier.issn 1097-4172 (online)
dc.identifier.other 10.1016/j.cell.2017.08.049
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2017 Elsevier Inc. Notice : this is the author’s version of a work that was accepted for publication in Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Cell, vol. 171, no. 1, pp. 59-71.e21, 2017. doi : 10.1016/j.cell.2017.08.049. en_ZA
dc.subject Adaptation en_ZA
dc.subject Africa en_ZA
dc.subject Ancient DNA en_ZA
dc.subject Hunter-gatherers en_ZA
dc.subject Natural selection en_ZA
dc.subject Population genetics en_ZA
dc.subject Population history en_ZA
dc.title Reconstructing prehistoric African population structure en_ZA
dc.type Postprint Article en_ZA

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