Reconstructing prehistoric African population structure

dc.contributor.authorSkoglund, Pontus
dc.contributor.authorThompson, Jessica C.
dc.contributor.authorPrendergast, Mary E.
dc.contributor.authorMittnik, Alissa
dc.contributor.authorSirak, Kendra
dc.contributor.authorHajdinjak, Mateja
dc.contributor.authorSalie, Tasneem
dc.contributor.authorRohland, Nadin
dc.contributor.authorMallick, Swapan
dc.contributor.authorPeltzer, Alexander
dc.contributor.authorHeinze, Anja
dc.contributor.authorOlalde, Iñigo
dc.contributor.authorFerry, Matthew
dc.contributor.authorHarney, Eadaoin
dc.contributor.authorMichel, Megan
dc.contributor.authorStewardson, Kristin
dc.contributor.authorCerezo-Román, Jessica I.
dc.contributor.authorChiumia, Chrissy
dc.contributor.authorCrowther, Alison
dc.contributor.authorGomani-Chindebvu, Elizabeth
dc.contributor.authorGidna, Agness O.
dc.contributor.authorGrillo, Katherine M.
dc.contributor.authorHelenius, I. Taneli
dc.contributor.authorHellenthal, Garrett
dc.contributor.authorHelm, Richard
dc.contributor.authorHorton, Mark
dc.contributor.authorLópez, Saioa
dc.contributor.authorMabulla, Audax Z.P.
dc.contributor.authorParkington, John
dc.contributor.authorShipton, Ceri
dc.contributor.authorThomas, Mark G.
dc.contributor.authorTibesasa, Ruth
dc.contributor.authorWelling, Menno
dc.contributor.authorHayes, Vanessa M.
dc.contributor.authorKennett, Douglas J.
dc.contributor.authorRamesar, Raj
dc.contributor.authorMeyer, Matthias
dc.contributor.authorPääbo, Svante
dc.contributor.authorPatterson, Nick
dc.contributor.authorMorris, Alan G.
dc.contributor.authorBoivin, Nicole
dc.contributor.authorPinhasi, Ron
dc.contributor.authorKrause, Johannes
dc.contributor.authorReich, David
dc.date.accessioned2017-10-19T06:38:13Z
dc.date.issued2017-09
dc.description.abstractWe assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers ∼8,100–2,500 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers ∼1,400 years ago. We document how the spread of farmers from western Africa involved complete replacement of local hunter-gatherers in some regions, and we track the spread of herders by showing that the population of a ∼3,100-year-old pastoralist from Tanzania contributed ancestry to people from northeastern to southern Africa, including a ∼1,200-year-old southern African pastoralist. The deepest diversifications of African lineages were complex, involving either repeated gene flow among geographically disparate groups or a lineage more deeply diverging than that of the San contributing more to some western African populations than to others. We finally leverage ancient genomes to document episodes of natural selection in southern African populations.en_ZA
dc.description.departmentAnthropology and Archaeologyen_ZA
dc.description.departmentSchool of Health Systems and Public Health (SHSPH)en_ZA
dc.description.embargo2018-09-21
dc.description.librarianhj2017en_ZA
dc.description.sponsorshipP.S. was supported by the Wenner-Gren Foundation and the Swedish Research Council (VR grant 2014-453). J.C.T was supported by a grant from the Program for the Enhancement of Research at Emory University. J.K. and A.M. were supported by the DFG grant KR 4015/1-1 and the Max Planck Society. K.Si. was supported by NSF grant BCS-1613577. M.Ha., A.H., M.Me., and S.P. were supported by the Max Planck Society. A.G.M. and J.P. were supported by the National Research Foundation of South Africa. R.R. was supported by the South African Medical Research Council. N.B. was supported by ERC starting grant SEALINKS (206148), and R.P. was supported by ERC starting grant ADNABIOARC (263441). M.G.T. was supported by Wellcome Trust Senior Investigator Award (grant number 100719/Z/12/Z). D.R. was supported by NIH grant GM100233 and by NSFHOMINID BCS-1032255 and is a Howard Hughes Medical Institute investigator. The laboratory at Penn State was supported by the NSF Archaeometry program (BCS-1460369, D.J.K.).en_ZA
dc.description.urihttp://www.cell.comen_ZA
dc.identifier.citationSkoglund, P., Thompson, J.C., Prendergast, M.E. ... et al. 2017, 'Reconstructing prehistoric African population structure', Cell, vol. 171, no. 1, pp. 59-71.e21.en_ZA
dc.identifier.issn0092-8674 (print)
dc.identifier.issn1097-4172 (online)
dc.identifier.other10.1016/j.cell.2017.08.049
dc.identifier.urihttp://hdl.handle.net/2263/62836
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Elsevier Inc. Notice : this is the author’s version of a work that was accepted for publication in Cell. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Cell, vol. 171, no. 1, pp. 59-71.e21, 2017. doi : 10.1016/j.cell.2017.08.049.en_ZA
dc.subjectAdaptationen_ZA
dc.subjectAfricaen_ZA
dc.subjectAncient DNAen_ZA
dc.subjectHunter-gatherersen_ZA
dc.subjectNatural selectionen_ZA
dc.subjectPopulation geneticsen_ZA
dc.subjectPopulation historyen_ZA
dc.titleReconstructing prehistoric African population structureen_ZA
dc.typePostprint Articleen_ZA

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