The neglected burden of tuberculosis disease among health workers : a decade-long cohort study in South Africa

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dc.contributor.author O’Hara, Lyndsay M.
dc.contributor.author Yassi, Annalee
dc.contributor.author Zungu, Muzimkhulu
dc.contributor.author Malotle, Molebogeng
dc.contributor.author Bryce, Elizabeth A.
dc.contributor.author Barker, Stephen J.
dc.contributor.author Darwin, Lincoln
dc.contributor.author FitzGerald, J. Mark
dc.date.accessioned 2017-09-12T09:27:03Z
dc.date.available 2017-09-12T09:27:03Z
dc.date.issued 2017-08-07
dc.description Additional file 1: Record linkage technical appendix. en_ZA
dc.description.abstract BACKGROUND : Health workers (HWs) in resource-limited settings are at high-risk of exposure to tuberculosis (TB) at work. The aim of this study was to estimate the rate of TB disease among HWs in the Free State Province of South Africa between 2002 and 2012 and to compare demographic and clinical characteristics between HWs and the general population with TB. This study also explores the effect of occupational variables on risk of TB among HWs. METHODS : Probabilistic record linkage was utilized to identify HWs who were also registered as TB patients. This historical prospective cohort study calculated incidence rate ratios (IRR) for TB disease among HWs in Free State from 2002 to 2012. Generalized linear mixed-effects regression was used to model the association between sex, race, facility type, occupation, duration of employment, and the rate of TB. RESULTS : There were 2677 cases of TB diagnosed among HWs from 2002 to 2012 and 1280 cases were expected. The overall TB incidence rate in HWs during the study period was 1496·32 per 100,000 compared to an incidence rate of 719·37 per 100,000 in the general population during the same time period. IRR ranged from 1·14 in 2012 to 3·12 in 2005. HWs who were male, black, coloured and employed less than 20 years had higher risk of TB. Facility type and occupation were not associated with increased risk of TB when adjusted for other covariates. CONCLUSION : HWs in South Africa have higher rates of TB than the general population. Improved infection prevention and control measures are necessary in all high-burden TB healthcare settings. en_ZA
dc.description.department School of Health Systems and Public Health (SHSPH) en_ZA
dc.description.librarian am2017 en_ZA
dc.description.sponsorship The Canadian Institutes for Health Research (grant number ROH-115212) en_ZA
dc.description.uri http://www.biomedcentral.com/bmcinfectdis en_ZA
dc.identifier.citation O'Hara, L.M., Yassi, A., Zungu, M., Malotle, M., Bryce, E.A, Barker, S.J., Darwin, L. & Mark FitzGerald, J. 2017, 'The neglected burden of tuberculosis disease among health workers : a decade-long cohort study in South Africa', BMC Infectious Diseases, vol. 17, art. no. 547, pp. 1-11. en_ZA
dc.identifier.issn 1471-2334 (online)
dc.identifier.other 10.1186/s12879-017-2659-3
dc.identifier.uri http://hdl.handle.net/2263/62239
dc.language.iso en en_ZA
dc.publisher BioMed Central en_ZA
dc.rights © The Author(s). 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. en_ZA
dc.subject Free State Province, South Africa en_ZA
dc.subject Tuberculosis (TB) en_ZA
dc.subject Health workers (HWs) en_ZA
dc.subject Incidence rate ratios (IRR) en_ZA
dc.title The neglected burden of tuberculosis disease among health workers : a decade-long cohort study in South Africa en_ZA
dc.type Article en_ZA


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