Synthetic approaches to radiochemical probes for imaging of bacterial infections

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Authors

Dutta, Jyotibon
Naicker, Tricia
Ebenhan, Thomas
Kruger, Hendrik G.
Arvidsson, Per I.
Govender, Thavendran

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Elsevier

Abstract

This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes fortomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions procedures for the preparation of the probes.

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Keywords

White cell scintigraphy, Staphylococcus-aureus infection, Inflammatory-bowel-disease, Colloid-labeled-leukocytes, Antimicrobial peptide (AMP), Escherichia coli, In-vitro, Biologival evaluation, Mycobacterium tuberculosis (MTB), Positron emission tomography (PET)

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Citation

Dutta, J., Naicker, T., Ebenhan, T., Kruger, H.G., Arvidsson, P.I. & Govender, T. 2017, 'Synthetic approaches to radiochemical probes for imaging of bacterial infections', European Journal of Medicinal Chemistry, vol. 133, pp. 287-308.