Synthetic approaches to radiochemical probes for imaging of bacterial infections
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Date
Authors
Dutta, Jyotibon
Naicker, Tricia
Ebenhan, Thomas
Kruger, Hendrik G.
Arvidsson, Per I.
Govender, Thavendran
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes fortomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions procedures for the preparation of the probes.
Description
Keywords
White cell scintigraphy, Staphylococcus-aureus infection, Inflammatory-bowel-disease, Colloid-labeled-leukocytes, Antimicrobial peptide (AMP), Escherichia coli, In-vitro, Biologival evaluation, Mycobacterium tuberculosis (MTB), Positron emission tomography (PET)
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Citation
Dutta, J., Naicker, T., Ebenhan, T., Kruger, H.G., Arvidsson, P.I. & Govender, T. 2017, 'Synthetic approaches to radiochemical probes for imaging of bacterial infections', European Journal of Medicinal Chemistry, vol. 133, pp. 287-308.