Synthetic approaches to radiochemical probes for imaging of bacterial infections

dc.contributor.authorDutta, Jyotibon
dc.contributor.authorNaicker, Tricia
dc.contributor.authorEbenhan, Thomas
dc.contributor.authorKruger, Hendrik G.
dc.contributor.authorArvidsson, Per I.
dc.contributor.authorGovender, Thavendran
dc.date.accessioned2017-07-19T07:28:36Z
dc.date.issued2017-06
dc.description.abstractThis present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes fortomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions procedures for the preparation of the probes.en_ZA
dc.description.departmentNuclear Medicineen_ZA
dc.description.embargo2018-06-16
dc.description.librarianhj2017en_ZA
dc.description.urihttp://www.elsevier.com/locate/ejmechen_ZA
dc.identifier.citationDutta, J., Naicker, T., Ebenhan, T., Kruger, H.G., Arvidsson, P.I. & Govender, T. 2017, 'Synthetic approaches to radiochemical probes for imaging of bacterial infections', European Journal of Medicinal Chemistry, vol. 133, pp. 287-308.en_ZA
dc.identifier.issn1768-3254 (online
dc.identifier.issn0223-5234 (print)
dc.identifier.other10.1016/j.ejmech.2017.03.060
dc.identifier.urihttp://hdl.handle.net/2263/61374
dc.language.isoenen_ZA
dc.publisherElsevieren_ZA
dc.rights© 2017 Elsevier Masson SAS. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in European Journal of Medicinal Chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in European Journal of Medicinal Chemistry, vol. 133, pp. 287-308, 2017. doi : 10.1016/j.ejmech.2017.03.060.en_ZA
dc.subjectWhite cell scintigraphyen_ZA
dc.subjectStaphylococcus-aureus infectionen_ZA
dc.subjectInflammatory-bowel-diseaseen_ZA
dc.subjectColloid-labeled-leukocytesen_ZA
dc.subjectAntimicrobial peptide (AMP)en_ZA
dc.subjectEscherichia colien_ZA
dc.subjectIn-vitroen_ZA
dc.subjectBiologival evaluationen_ZA
dc.subjectMycobacterium tuberculosis (MTB)en_ZA
dc.subjectPositron emission tomography (PET)en_ZA
dc.titleSynthetic approaches to radiochemical probes for imaging of bacterial infectionsen_ZA
dc.typePostprint Articleen_ZA

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