Bioclimatological studies on white rats in South Africa. No 1. Skin cancer in rats following continued exposure to sunlight

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dc.contributor.author De Kock, G.
dc.contributor.author Quin, J.I.
dc.contributor.editor Du Toit, P.J.
dc.date.accessioned 2017-04-12T12:07:56Z
dc.date.available 2017-04-12T12:07:56Z
dc.date.created 2017
dc.date.issued 1948
dc.description The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract 1. Skin cancer in rats (and in mice) can be produced by exposing them daily for definite periods to ultraviolet light. 2. Roffo produced identical neoplasms in rats by exposing them daily for 5 hours to sunlight. This was confirmed in the experiments at Onderstepoort, where rats were daily exposed for 4.5 hours to sunlight. In one instance a new growth developed in a rat exposed daily for only 2.5 hours. 3. So far no spontaneous skin cancer have been observed in the rats at Onderstepoort when kept under sheltered conditions but in one rat in these experiments, a fibroblastic sarcoma was found in the liver, lung, and omentum. 4. The skin cancers occurred on the hairless parts of the skin, and in the majority of rats new growths appeared in more than one place on the body. The ears were most frequently affected. 5. There was no definite occurrence of metastasis into other organs. 6. The earliest appearance of a new growth, to which attention is drawn, was ±10 months after exposure of the rats to sunlight. 7. In all the new growths a microscopical diagnosis of an epidermoid carcinoma was made. The statement by Roffo that some of these neoplasms were of the nature of sarcoma could not be confirmed at Onderstepoort. 8. The earlier lesions revealed the usual characteristics of an acanthoma associated in some cases with hyperkeratosis, while in the large actively growing neoplasms there was much evidence of anaplasia. en_ZA
dc.identifier.citation De Kock, G & Quin, JI 1948, 'Bioclimatological studies on white rats in South Africa. No 1. Skin cancer in rats following continued exposure to sunlight’, Onderstepoort Journal of Veterinary Science and Animal Industry, vol. 23, nos. 1 & 2, pp. 349-365. en_ZA
dc.identifier.issn 0330-2465
dc.identifier.uri http://hdl.handle.net/2263/59916
dc.language.iso en en_ZA
dc.publisher Pretoria : The Government Printer en_ZA
dc.rights © 1948 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2017 University of Pretoria. Dept. of Library Services (digital). en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title Bioclimatological studies on white rats in South Africa. No 1. Skin cancer in rats following continued exposure to sunlight en_ZA
dc.type Article en_ZA


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