The effect of inflammation on the development of immunity to anthrax in guinea pigs

Abstract

1. An acute inflammation has the same general inhibitory effect on immunizing power that it has on the virulence of anthrax strains. 2. Irritant excipients have the same local stimulating effect on small immunizing doses of anthrax that they have on small virulent doses. 3. The apparent difference in the effect of irritants on small and on large immunizing doses of spores is because the raising of a sub-immunizing dose to a full immunizing is far more perceptible than the same order of increase of a large dose. 4. The probable advantages of using 20 per cent. NaCl solution as an excipient are pointed out. The bearing of these findings on earlier reports is discussed.