dc.contributor.author |
Coertse, Jessica
|
|
dc.contributor.author |
Markotter, Wanda
|
|
dc.contributor.author |
Le Roux, Kevin
|
|
dc.contributor.author |
Stewart, Daniel
|
|
dc.contributor.author |
Sabeta, Claude Taurai
|
|
dc.contributor.author |
Nel, Louis Hendrik
|
|
dc.date.accessioned |
2017-03-29T05:55:55Z |
|
dc.date.available |
2017-03-29T05:55:55Z |
|
dc.date.issued |
2017-01-31 |
|
dc.description |
Additional file 1: Table S1. Primers and PCR conditions for
amplification of the Nucleoprotein-, Phosphoprotein-, Matrix protein- and
Glycoprotein genes of Mokola virus isolates. |
en_ZA |
dc.description |
Additional file 2: Table S2. Details of sequences used for the Bayesian
analysis of the rabies virus positive samples. |
en_ZA |
dc.description |
Additional file 3: Table S3. Details of sequences used for the Bayesian
analysis of the new Mokola virus isolates. |
en_ZA |
dc.description |
Additional file 4: Figure S1. Bayesian analysis of the coding region of
the Nucleoprotein gene (1353 bp) of all Mokola virus isolates (Additional
file 3: Table S3) applying the general time reversible substitution model
with invariable sites. Laboratory reference numbers are shown for all
sequences, followed by the host species, country of origin (KZN SA:
KwaZulu-Natal province, South Africa; EC SA: Eastern Cape province South
Africa; ZIM: Zimbabwe; CAR: Central African Republic; NIG: Nigeria) and
year of isolation. |
en_ZA |
dc.description |
Additional file 5: Figure S2. Bayesian analysis of the coding region of
the Phosphoprotein gene (913 bp) applying the general time reversible
substitution model with gamma distribution. Laboratory reference
numbers are shown for all sequences, followed by the host species,
country of origin (KZN SA: KwaZulu-Natal province, South Africa; EC SA:
Eastern Cape province South Africa; ZIM: Zimbabwe; CAR: Central African
Republic; NIG: Nigeria) and year of isolation. |
en_ZA |
dc.description |
Additional file 6: Figure S3. Bayesian analysis of the coding region of
the Matrix protein gene (609 bp) applying the general time reversible
substitution model with gamma distribution. Laboratory reference numbers
are shown for all sequences, followed by the host species, country of origin
(KZN SA: KwaZulu-Natal province, South Africa; EC SA: Eastern Cape province
South Africa; ZIM: Zimbabwe; CAR: Central African Republic; NIG: Nigeria)
and year of isolation. |
en_ZA |
dc.description |
Additional file 7: Figure S4. Bayesian analysis of the coding region of
the Glycoprotein gene (1569 bp) applying the general time reversible
substitution model with gamma distribution and invariable sites.
Laboratory reference numbers are shown for all sequences, followed by
the host species, country of origin (KZN SA: KwaZulu-Natal province,
South Africa; EC SA: Eastern Cape province South Africa; ZIM: Zimbabwe;
CAR: Central African Republic; NIG: Nigeria) and year of isolation. |
en_ZA |
dc.description |
Additional file 8: Table S4. Nucleotide identity of the Nucleoprotein
gene of all Mokola virus isolates. |
en_ZA |
dc.description |
Additional file 9: Table S5. Nucleotide identity of the Phosphoprotein
gene of all Mokola virus isolates. |
en_ZA |
dc.description |
Additional file 10: Table S6. Nucleotide identity of the Matrix protein
gene of all Mokola virus isolates. |
en_ZA |
dc.description |
Additional file 11: Table S7. Nucleotide identity of the Glycoprotein
gene of all Mokola virus isolates. |
en_ZA |
dc.description.abstract |
BACKGROUND : Mokola virus (MOKV) is a rabies-related lyssavirus and appears to be exclusive to the African continent.
Only 24 cases of MOKV, which includes two human cases, have been reported since its identification in 1968. MOKV
has an unknown reservoir host and current commercial vaccines do not confer protection against MOKV.
RESULTS : We describe three new isolations of MOKV from domestic cats in South Africa. Two cases were retrospectively
identified from 2012 and an additional one in 2014.
CONCLUSIONS : These cases emphasize the generally poor surveillance for rabies-related lyssaviruses and our inadequate
comprehension of the epidemiology and ecology of Mokola lyssavirus per se. |
en_ZA |
dc.description.department |
Medical Virology |
en_ZA |
dc.description.department |
Microbiology and Plant Pathology |
en_ZA |
dc.description.librarian |
am2017 |
en_ZA |
dc.description.sponsorship |
This work was partially funded by the National Research Foundation (Grant
UID 92524 & RISP grant UID78566), the Poliomyelitis Research Foundation
(Grant no. 10/40, 12/14) and the Animal and Zoonotic Diseases Institutional
Research Theme of the University of Pretoria. |
en_ZA |
dc.description.uri |
http://www.biomedcentral.com/bmcvetres |
en_ZA |
dc.identifier.citation |
Coertse, J, Markotter, W, le Roux, K, Stewart, D, Sabeta, CT & Nel, LH 2017, 'New isolations of the rabies-related Mokola virus from South Africa', BMC Veterinary Research, vol. 13, art. no. 37, pp. 1-8. |
en_ZA |
dc.identifier.issn |
1746-6148 |
|
dc.identifier.other |
10.1186/s12917-017-0948-0 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/59559 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
BioMed Central |
en_ZA |
dc.rights |
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. |
en_ZA |
dc.subject |
Lyssavirus |
en_ZA |
dc.subject |
Rabies-related |
en_ZA |
dc.subject |
South Africa (SA) |
en_ZA |
dc.subject |
Mokola virus (MOKV) |
en_ZA |
dc.title |
New isolations of the rabies-related Mokola virus from South Africa |
en_ZA |
dc.type |
Article |
en_ZA |