Skeletal manifestations of tuberculosis in modern human remains

Show simple item record Steyn, Maryna Buskes, Jenifer 2017-03-09T09:26:37Z 2016-10
dc.description.abstract Paleopathologists study the presence of diseases in the past and as such have a vast knowledge of skeletal changes associated with different conditions. Tuberculosis is one of the most studied diseases and still remains a major health problem today. Its manifestations in past populations have been extensively described, but less is known about its bony involvement in the post-antibiotic era. The aim of this study was to assess the frequency and manifestations of skeletal lesions in the post-antibiotic era in a South African sample and compare it to that found before the introduction of antibiotics. Skeletons of 205 individuals from modern skeletal collections and who are known to have died from TB were assessed. It was found that 39.2% of all individuals dying in the post-antibiotic era showed skeletal changes that could be associated with TB, while another 27.5% showed nonspecific changes. The highest incidences were found in individuals who died after 1985, when coinfection with HIV and drug resistance became common. While, as expected, vertebral and rib changes were the most common, the number of individuals who showed changes to the skull, and specifically intracranially, was surprising. These could most probably be associated with TB meningitis, although this specific cause of death was noted in only a few individuals. It seems that individuals may be living longer as a result of long-term antibiotic use, leaving more time for lesions to develop. en_ZA
dc.description.department Anatomy en_ZA
dc.description.embargo 2017-10-31
dc.description.librarian hb2017 en_ZA
dc.description.sponsorship The research of M. Steyn is supported by the National Research Foundation of South Africa (NRF). en_ZA
dc.description.uri en_ZA
dc.identifier.citation Steyn, M & Buskes, J 2016, 'Skeletal manifestations of tuberculosis in modern human remains', Clinical Anatomy, vol. 29, no. 7, pp. 854-861. en_ZA
dc.identifier.issn 0897-3806 (print)
dc.identifier.issn 1098-2353 (online)
dc.identifier.other 10.1002/ca.22688
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2016 Wiley Periodicals Inc. This is the pre-peer reviewed version of the following article : Skeletal manifestations of tuberculosis in modern human remains, Clinical Anatomy, vol. 29, no. 7, pp. 854-861, 2016. doi : 10.1002/ca.22688, which has been published in final form at http://onlinelibrary.wiley.comjournal/10.1002/(ISSN)1098-2353. en_ZA
dc.subject Paleopathology en_ZA
dc.subject Post-antibiotic en_ZA
dc.subject Evolution of disease en_ZA
dc.subject Tuberculosis (TB) en_ZA
dc.title Skeletal manifestations of tuberculosis in modern human remains en_ZA
dc.type Postprint Article en_ZA

Files in this item

This item appears in the following Collection(s)

Show simple item record