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dc.contributor.author | Ondua, M.![]() |
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dc.contributor.author | Adebayo, Salmon A.![]() |
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dc.contributor.author | Shai, L.J.![]() |
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dc.contributor.author | Lebelo, S.L.![]() |
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dc.date.accessioned | 2016-11-14T05:42:35Z | |
dc.date.available | 2016-11-14T05:42:35Z | |
dc.date.issued | 2016 | |
dc.description.abstract | The biological activities of 4 medicinal plants (Acokanthera oppositifolia, Plantago lanceolata, Artemisia vulgaris and Conyza canadensis) were investigated. These plant extracts were subjected to screening for their possible effects as analgesic, and anti-inflammatory agents. The plant materials (only leaves were used in this study) were used in 4 solvents (acetone, ethyl acetate, chloroform and hexane). Plantago lanceolata hexane leaf extract inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.41 μg/mL. Quercetin, positive control in this study inhibited COX-2 with a recorded IC50 = 8.39 μg/mL. However, the COX-1 inhibition by same extract indicated an IC50 of 68.99 μg/mL compared to the positive control (quercetin), whose activity was represented with an IC50 value of 4.6 μg/mL. The lipoxygenase assay indicated that Plantago lanceolata hexane extract and Acokanthera oppositifolia acetone extract were the most active samples with an IC50 of 4.75 μg/mL and 7.73 μg/mL. Plantago lanceolata hexane extract was the most active in all enzyme inhibitions, revealing the great potential it presents as a source of new anti-oxidative, analgesic and anti-inflammatory drugs, with less adverse effects. | en_ZA |
dc.description.department | Paraclinical Sciences | en_ZA |
dc.description.librarian | am2016 | en_ZA |
dc.description.uri | www.ijppr.com | en_ZA |
dc.identifier.citation | Ondua, M, Adebayo, SA, Shai, LJ & Lebelo, SL 2016, 'The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa', International Journal of Pharmacognosy and Phytochemical Research, vol. 8, no. 10, pp. 1571-1575. | en_ZA |
dc.identifier.issn | 0975-4873 | |
dc.identifier.uri | http://hdl.handle.net/2263/57940 | |
dc.language.iso | en | en_ZA |
dc.publisher | INDIA Publishers | en_ZA |
dc.rights | INDIA Publishers | en_ZA |
dc.subject | Plantago lanceolata | en_ZA |
dc.subject | Conyza canadensis | en_ZA |
dc.subject | Acokantera oppositifolia | en_ZA |
dc.subject | Artemisia vulgaris | en_ZA |
dc.subject | Anti-inflammatory | en_ZA |
dc.subject | Lipoxygenase | en_ZA |
dc.subject | Cyclooxygenase-1 | en_ZA |
dc.subject | Cyclooxygenase-2 | en_ZA |
dc.title | The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa | en_ZA |
dc.type | Article | en_ZA |