The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa

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dc.contributor.author Ondua, M.
dc.contributor.author Adebayo, S.A.
dc.contributor.author Shai, L.J.
dc.contributor.author Lebelo, S.L.
dc.date.accessioned 2016-11-14T05:42:35Z
dc.date.available 2016-11-14T05:42:35Z
dc.date.issued 2016
dc.description.abstract The biological activities of 4 medicinal plants (Acokanthera oppositifolia, Plantago lanceolata, Artemisia vulgaris and Conyza canadensis) were investigated. These plant extracts were subjected to screening for their possible effects as analgesic, and anti-inflammatory agents. The plant materials (only leaves were used in this study) were used in 4 solvents (acetone, ethyl acetate, chloroform and hexane). Plantago lanceolata hexane leaf extract inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.41 μg/mL. Quercetin, positive control in this study inhibited COX-2 with a recorded IC50 = 8.39 μg/mL. However, the COX-1 inhibition by same extract indicated an IC50 of 68.99 μg/mL compared to the positive control (quercetin), whose activity was represented with an IC50 value of 4.6 μg/mL. The lipoxygenase assay indicated that Plantago lanceolata hexane extract and Acokanthera oppositifolia acetone extract were the most active samples with an IC50 of 4.75 μg/mL and 7.73 μg/mL. Plantago lanceolata hexane extract was the most active in all enzyme inhibitions, revealing the great potential it presents as a source of new anti-oxidative, analgesic and anti-inflammatory drugs, with less adverse effects. en_ZA
dc.description.department Paraclinical Sciences en_ZA
dc.description.librarian am2016 en_ZA
dc.description.uri www.ijppr.com en_ZA
dc.identifier.citation Ondua, M, Adebayo, SA, Shai, LJ & Lebelo, SL 2016, 'The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa', International Journal of Pharmacognosy and Phytochemical Research, vol. 8, no. 10, pp. 1571-1575. en_ZA
dc.identifier.issn 0975-4873
dc.identifier.uri http://hdl.handle.net/2263/57940
dc.language.iso en en_ZA
dc.publisher INDIA Publishers en_ZA
dc.rights INDIA Publishers en_ZA
dc.subject Plantago lanceolata en_ZA
dc.subject Conyza canadensis en_ZA
dc.subject Acokantera oppositifolia en_ZA
dc.subject Artemisia vulgaris en_ZA
dc.subject Anti-inflammatory en_ZA
dc.subject Lipoxygenase en_ZA
dc.subject Cyclooxygenase-1 en_ZA
dc.subject Cyclooxygenase-2 en_ZA
dc.title The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa en_ZA
dc.type Article en_ZA


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