The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa

dc.contributor.authorOndua, M.
dc.contributor.authorAdebayo, Salmon A.
dc.contributor.authorShai, L.J.
dc.contributor.authorLebelo, S.L.
dc.date.accessioned2016-11-14T05:42:35Z
dc.date.available2016-11-14T05:42:35Z
dc.date.issued2016
dc.description.abstractThe biological activities of 4 medicinal plants (Acokanthera oppositifolia, Plantago lanceolata, Artemisia vulgaris and Conyza canadensis) were investigated. These plant extracts were subjected to screening for their possible effects as analgesic, and anti-inflammatory agents. The plant materials (only leaves were used in this study) were used in 4 solvents (acetone, ethyl acetate, chloroform and hexane). Plantago lanceolata hexane leaf extract inhibited cyclooxygenase-2 (COX-2) activity with an IC50 value of 0.41 μg/mL. Quercetin, positive control in this study inhibited COX-2 with a recorded IC50 = 8.39 μg/mL. However, the COX-1 inhibition by same extract indicated an IC50 of 68.99 μg/mL compared to the positive control (quercetin), whose activity was represented with an IC50 value of 4.6 μg/mL. The lipoxygenase assay indicated that Plantago lanceolata hexane extract and Acokanthera oppositifolia acetone extract were the most active samples with an IC50 of 4.75 μg/mL and 7.73 μg/mL. Plantago lanceolata hexane extract was the most active in all enzyme inhibitions, revealing the great potential it presents as a source of new anti-oxidative, analgesic and anti-inflammatory drugs, with less adverse effects.en_ZA
dc.description.departmentParaclinical Sciencesen_ZA
dc.description.librarianam2016en_ZA
dc.description.uriwww.ijppr.comen_ZA
dc.identifier.citationOndua, M, Adebayo, SA, Shai, LJ & Lebelo, SL 2016, 'The anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africa', International Journal of Pharmacognosy and Phytochemical Research, vol. 8, no. 10, pp. 1571-1575.en_ZA
dc.identifier.issn0975-4873
dc.identifier.urihttp://hdl.handle.net/2263/57940
dc.language.isoenen_ZA
dc.publisherINDIA Publishersen_ZA
dc.rightsINDIA Publishersen_ZA
dc.subjectPlantago lanceolataen_ZA
dc.subjectConyza canadensisen_ZA
dc.subjectAcokantera oppositifoliaen_ZA
dc.subjectArtemisia vulgarisen_ZA
dc.subjectAnti-inflammatoryen_ZA
dc.subjectLipoxygenaseen_ZA
dc.subjectCyclooxygenase-1en_ZA
dc.subjectCyclooxygenase-2en_ZA
dc.titleThe anti-inflammatory and anti-nociceptive activities of some medicinal plant species used to treat inflammatory pain conditions in Southern Africaen_ZA
dc.typeArticleen_ZA

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