Changes in red blood cell membrane structure in type 2 diabetes : a scanning electron and atomic force microscopy study

Show simple item record Buys, A.V. (Antonia Vergina) Van Rooy, Mia-Jeanne Soma, Prashilla Van Papendorp, D.H. (Dirk Hermanus), 1949- Lipinski, Boguslaw Pretorius, Etheresia 2016-10-31T11:20:23Z 2016-10-31T11:20:23Z 2013-01-28
dc.description.abstract Red blood cells (RBCs) are highly deformable and possess a robust membrane that can withstand shear force. Previous research showed that in diabetic patients, there is a changed RBC ultrastructure, where these cells are elongated and twist around spontaneously formed fibrin fibers. These changes may impact erythrocyte function. Ultrastructural analysis of RBCs in inflammatory and degenerative diseases can no longer be ignored and should form a fundamental research tool in clinical studies. Consequently, we investigated the membrane roughness and ultrastructural changes in type 2 diabetes. Atomic force microscopy (AFM) was used to study membrane roughness and we correlate this with scanning electron microscopy (SEM) to compare results of both the techniques with the RBCs of healthy individuals. We show that the combined AFM and SEM analyses of RBCs give valuable information about the disease status of patients with diabetes. Effectiveness of treatment regimes on the integrity, cell shape and roughness of RBCs may be tracked, as this cell’s health status is crucial to the overall wellness of the diabetic patient. en_ZA
dc.description.department Physiology en_ZA
dc.description.librarian am2016 en_ZA
dc.description.uri en_ZA
dc.identifier.citation Buys, AV, Van Rooy, MJ, Soma, P, Van Papendorp, D, Lipinski, B & Pretorius, E 2013, 'Changes in red blood cell membrane structure in type 2 diabetes: a scanning electron and atomic force microscopy study', Cardiovascular Diabetology, vol. 12, art. # 25, pp. 1-6. en_ZA
dc.identifier.issn 1475-2840
dc.identifier.other 10.1186/1475-2840-12-25
dc.language.iso en en_ZA
dc.publisher BioMed Central en_ZA
dc.rights © 2013 Buys et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. en_ZA
dc.subject Atomic force microscopy en_ZA
dc.subject Red blood cells (RBCs) en_ZA
dc.subject Scanning electron microscopy (SEM) en_ZA
dc.subject Type 2 diabetes (T2D) en_ZA
dc.title Changes in red blood cell membrane structure in type 2 diabetes : a scanning electron and atomic force microscopy study en_ZA
dc.type Article en_ZA

Files in this item

This item appears in the following Collection(s)

Show simple item record