Synthetic hormones and clot formation

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dc.contributor.author Swanepoel, A.C. (Albe Carina)
dc.contributor.author Visagie, Amcois
dc.contributor.author Pretorius, Etheresia
dc.date.accessioned 2016-10-27T10:52:43Z
dc.date.issued 2016-08
dc.description.abstract Combined oral contraceptives (COCs), colloquially referred to as "the pill," have been regarded as a medical breakthrough, as they have improved the lives of countless women, from simplifying family planning to the treatment of acne, endometriosis, polycystic ovarian syndrome, and dysmenorrhea. Unfortunately, COC usage has been associated with an increased occurrence of venous thrombosis and therefore a systemic hypercoagulable state in susceptible females. Here we discuss the health risks of COC usage and use viscoelastic and morphological techniques to investigate the effect of different COC constituents on clot formation, particularly fibrin network packaging and whole blood viscoelasticity. Viscoelastic properties of whole blood showed gender-specific changes while morphological alterations were person-specific, regardless of gender. Using scanning electron microscopy and thromboelastography provides great insight regarding fibrin packaging and the development of a hypercoagulable state in high-risk individuals. We proposed a three-step approach where (1) an individual's coagulation profile baseline is determined, after which (2) the "ideal" combination of constituents is prescribed, and (3) the coagulation profile of the individual is monitored to assess possible risk of thrombosis. Only in following such an individualized patient-oriented approach will we be able to avoid the many health issues due to COC usage in susceptible females. en_ZA
dc.description.department Physiology en_ZA
dc.description.embargo 2017-02-28
dc.description.librarian hb2016 en_ZA
dc.description.uri http://journals.cambridge.org/action/displayJournal?jid=MAM en_ZA
dc.identifier.citation Swanepoel, AC, Visagie, A & Pretorius, E 2016, 'Synthetic hormones and clot formation', Microscopy and Microanalysis, vol. 22, no. 4, pp. 878-886. en_ZA
dc.identifier.issn 1431-9276 (print)
dc.identifier.issn 1435-8115 (online)
dc.identifier.other 10.1017/S1431927616011478
dc.identifier.uri http://hdl.handle.net/2263/57531
dc.language.iso en en_ZA
dc.publisher Cambridge University Press en_ZA
dc.rights © Microscopy Society of America 2016 en_ZA
dc.subject Hypercoagulability en_ZA
dc.subject Morphology en_ZA
dc.subject Venous thrombosis en_ZA
dc.subject Viscoelasticity en_ZA
dc.subject Combined oral contraceptives (COCs) en_ZA
dc.title Synthetic hormones and clot formation en_ZA
dc.type Postprint Article en_ZA


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