Synthetic hormones and clot formation

dc.contributor.authorSwanepoel, A.C. (Albe Carina)
dc.contributor.authorVisagie, Amcois
dc.contributor.authorPretorius, Etheresia
dc.contributor.emailalbe.swanepoel@up.ac.zaen_ZA
dc.date.accessioned2016-10-27T10:52:43Z
dc.date.issued2016-08
dc.description.abstractCombined oral contraceptives (COCs), colloquially referred to as "the pill," have been regarded as a medical breakthrough, as they have improved the lives of countless women, from simplifying family planning to the treatment of acne, endometriosis, polycystic ovarian syndrome, and dysmenorrhea. Unfortunately, COC usage has been associated with an increased occurrence of venous thrombosis and therefore a systemic hypercoagulable state in susceptible females. Here we discuss the health risks of COC usage and use viscoelastic and morphological techniques to investigate the effect of different COC constituents on clot formation, particularly fibrin network packaging and whole blood viscoelasticity. Viscoelastic properties of whole blood showed gender-specific changes while morphological alterations were person-specific, regardless of gender. Using scanning electron microscopy and thromboelastography provides great insight regarding fibrin packaging and the development of a hypercoagulable state in high-risk individuals. We proposed a three-step approach where (1) an individual's coagulation profile baseline is determined, after which (2) the "ideal" combination of constituents is prescribed, and (3) the coagulation profile of the individual is monitored to assess possible risk of thrombosis. Only in following such an individualized patient-oriented approach will we be able to avoid the many health issues due to COC usage in susceptible females.en_ZA
dc.description.departmentPhysiologyen_ZA
dc.description.embargo2017-02-28
dc.description.librarianhb2016en_ZA
dc.description.urihttp://journals.cambridge.org/action/displayJournal?jid=MAMen_ZA
dc.identifier.citationSwanepoel, AC, Visagie, A & Pretorius, E 2016, 'Synthetic hormones and clot formation', Microscopy and Microanalysis, vol. 22, no. 4, pp. 878-886.en_ZA
dc.identifier.issn1431-9276 (print)
dc.identifier.issn1435-8115 (online)
dc.identifier.other10.1017/S1431927616011478
dc.identifier.urihttp://hdl.handle.net/2263/57531
dc.language.isoenen_ZA
dc.publisherCambridge University Pressen_ZA
dc.rights© Microscopy Society of America 2016en_ZA
dc.subjectHypercoagulabilityen_ZA
dc.subjectMorphologyen_ZA
dc.subjectVenous thrombosisen_ZA
dc.subjectViscoelasticityen_ZA
dc.subjectCombined oral contraceptives (COCs)en_ZA
dc.titleSynthetic hormones and clot formationen_ZA
dc.typePostprint Articleen_ZA

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Swanepoel_Synthetic_2016.pdf
Size:
1.14 MB
Format:
Adobe Portable Document Format
Description:
Postprint Article

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description: