Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue
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Date
Authors
Wessels, Quenton
Pretorius, Etheresia
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Burn wound care today has a primary objective of temporary or permanent wound closure.
Commercially available engineered alternative tissues have become a valuable adjunct to
the treatment of burn injuries. Their constituents can be biological, alloplastic or a
combination of both. Here the authors describe the aspects of the development of a
siloxane epidermis for a collagen-glycosaminoglycan and for nylon-based artificial skin
replacement products. A method to fabricate an ultra-thin epidermal equivalent is
described. Pores, to allow the escape of wound exudate, were punched and a tri-filament
nylon mesh or collagen scaffold was imbedded and silicone polymerisation followed at
120°C for 5 minutes. The ultra-structure of these bilaminates was assessed through scanning
electron microscopy. An ultra-thin biomedical grade siloxane film was reliably created
through precision coating on a pre-treated polyethylene terephthalate carrier.
Description
Keywords
Bioengineered alternative tissue, Burn wound, Siloxane epidermis, Temporary skin substitute, Ultra-thin membrane
Sustainable Development Goals
Citation
Wessels, Q & Pretorius, E 2015, 'Development and ultra-structure of an ultra-thin silicone epidermis of bioengineered alternative tissue', International Wound Journal, vol. 12, no. 4, pp. 428-431