The occurrence of anti-retroviral compounds used for HIV treatment in South African surface water

Show simple item record Wood, Timothy Paul Duvenage, Cornelia S.J. Rohwer, Egmont Richard 2016-08-11T12:12:16Z 2016-08-11T12:12:16Z 2015-04
dc.description.abstract The study and quantification of personal care products, such as pharmaceuticals, in surface water has become popular in recent years; yet very little description of these compounds’ presence in South African surface water exists in the literature. Antiretrovirals (ARVs), used to treat human immunodeficiency virus (HIV) are rarely considered within this field. A new method for the simultaneous quantification of 12 antiretroviral compounds in surface water using the standard addition method is described. Water samples were concentrated by a generic automated solid phase extraction method and analysed by ultrahigh pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Substantial matrix effect was encountered in the samples with an average method detection limit of 90.4 ng/L. This is the first reported countrywide survey of South African surface water for the quantification of these compounds with average concentrations ranging between 26.5 and 430 ng/L. en_ZA
dc.description.department Chemistry en_ZA
dc.description.librarian hb2016 en_ZA
dc.description.sponsorship South African Military Health Services. en_ZA
dc.description.uri en_ZA
dc.identifier.citation Wood, TP, Duvenage, CSJ & Rohwer, ER 2015, 'The occurrence of anti-retroviral compounds used for HIV treatment in South African surface water', Environmental Pollution, vol. 199, pp. 235-243. en_ZA
dc.identifier.issn 0269-7491
dc.identifier.other 10.1016/j.envpol.2015.01.030
dc.language.iso en en_ZA
dc.publisher Elsevier en_ZA
dc.rights © 2015 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Pollution. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Environmental Pollution, vol. 199, pp. 235-243, 2015. doi : 10.1016/j.envpol.2015.01.030. en_ZA
dc.subject Surface water en_ZA
dc.subject LC-MS en_ZA
dc.subject Solid phase extraction en_ZA
dc.subject Personal care products en_ZA
dc.subject Human immunodeficiency virus (HIV) en_ZA
dc.subject Antiretrovirals (ARVs) en_ZA
dc.subject Ultrahigh pressure liquid chromatography (UHPLC) en_ZA
dc.subject Mass spectrometry (MS) en_ZA
dc.title The occurrence of anti-retroviral compounds used for HIV treatment in South African surface water en_ZA
dc.type Postprint Article en_ZA

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