A locally isolated bovine enterovirus designated echovirus SA-I was found to belong to the Weybridge serotype 134. The growth characteristics of the virus in a number of cell types were studied. Its replicative cycle and its effect on the metabolism of the host cell, studied by means of isotope-labelling techniques, closely resemble those of other enteroviruses. It was shown that the inhibitors of cellular RNA and protein synthesis are produced normally even if replication of the infecting virus is blocked by guanidine.
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