Amicarbalide : a therapeutic agent for anaplasmosis
Barrowman, P.R.; Coetzer, J.A.W.; Kellerman, T.S.; De Vos, A.J.; De Kock, V.E.; Bigalke, R.D.; Cameron, Colin McKenzie; Gilchrist, Frances M.C.; Morren, A.J.; Verster, Anna J.M.; Verwoerd, Daniel Wynand; Walker, Jane B.
When administered subcutaneously in 2 equal daily doses at a total dosage rate of 20 mg/kg, amicarbalide was found to be an effective agent for controlling acute infections of Anaplasma marginate and A. centrale in intact and splenectomized cattle. Attempts to sterilize patent and latent
Anaplasma infections, however, were unsuccessful. At total dosage rates of 40 mg/kg and higher, amicarbalide exhibited potent hepato- and nephrotoxic tendencies.
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