Alteration of reproductive function in the rat by cortisol acetate

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dc.contributor.author Van Rensburg, S.J.
dc.contributor.author Cupps, P.T.
dc.contributor.editor Jansen, B.C.
dc.date.accessioned 2016-07-07T07:46:50Z
dc.date.available 2016-07-07T07:46:50Z
dc.date.created 2016
dc.date.issued 1967
dc.description The journals have been scanned in colour with a HP 5590 scanner; 600 dpi. Adobe Acrobat v.11 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. en_ZA
dc.description.abstract The effects of cortisol acetate were studied on immature gonadotrophin treated rats, mature intact and hysterectomized cycling females, gestating and pseudopregnant subjects with pituitary implants, and mature males. Observations included growth, organ morphology, histological, follicular and corpora lutea counts and measurements, vaginal smears and ovarian progesterone assays. The diameters of larger follicles were potentiated and the incidence of follicles exhibiting histological atresia increased. Luteinization occurred more rapidly but many corpora lutea were cystic in treated immature rats. The cycles of mature rats exhibited dose-related prolongation of the dioestrous period which was unaffected by hysterectomy. Ovulation, conception, and nidation were unchanged by chronic treatment, but embryonic mortality was increased. The combined uterine-decidual tissue weight was inhibited to a greater extent than the various conceptus elements. Uterine growth was unaffected in pseudopregnant immature and mature rats, but under conditions of oestrogen predomination inhibition was marked. Ovarian progesterone concentration was reduced by treatment only in pregnant rats, and the significance of this finding is discussed. No evidence of alterations in the endogenous gonadotrophic secretions was found in any of these experiments. It is concluded that the administration of excess cortisol acetate exerted no true inhibitory influences on gonadal activity, unlike the potent inhibitory effects of adrenocorticotrophin. en_ZA
dc.description.sponsorship Imperial Cold Storage and Supply Ltd en_ZA
dc.identifier.citation Van Rensburg, SJ & Cupps, PT ‘Alteration of reproductive function in the rat by cortisol acetate’, Onderstepoort Journal of Veterinary Research, vol. 34, no. 2, pp. 673-688. en_ZA
dc.identifier.issn 0330-2465
dc.identifier.uri http://hdl.handle.net/2263/54098
dc.language.iso en en_ZA
dc.publisher Pretoria : The Government Printer en_ZA
dc.rights © 1967 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2016 University of Pretoria. Dept. of Library Services (digital). en_ZA
dc.subject Veterinary medicine en_ZA
dc.subject Rats en_ZA
dc.subject Reproduction en_ZA
dc.subject.lcsh Veterinary medicine -- South Africa
dc.title Alteration of reproductive function in the rat by cortisol acetate en_ZA
dc.type Article en_ZA


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