Enzymatic activation of Clostridium perfringens epsilon prototoxin and some biological properties of activated toxin
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Date
Authors
Worthington, R.W.
Mulders, M.S.G.
Van Rensburg, J.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Published by the Government Printer, Pretoria
Abstract
Maximal activation of Clostridium perfringens epsilon toxin was only achieved by the combined action of trypsin and chymotrypsin. Impure preparations of trypsin, presumably containing small amounts of chymotrypsin were more efficient in activating prototoxin than pure trypsin. Activated toxin was readily absorbed by brain tissue and smaller amounts were possibly absorbed by kidney tissue. Other tissues absorbed only very small amounts of toxin. Injection of mice with toxoid 3 h prior to challenge with toxin increased their resistance 32 times.
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Keywords
Veterinary medicine
Sustainable Development Goals
Citation
Worthington, RW, Mulders, MSG & Van Rensburg, JJ 1973, ‘Enzymatic activation of Clostridium perfringens epsilon prototoxin and some biological properties of activated toxin’, Onderstepoort Journal of Veterinary Research, vol. 40, no. 4, pp. 153-156.